SNORD50: SNORD50 is a small nucleolar RNA (snoRNA) that has been reported to have a tumor suppressive role in breast and prostate cancer [PMC7862062]. It is a member of the SNORD50 family, and SNORD50A is the most expressed member in most tissues, except in skeletal muscle where SNORD50B is more abundant [PMC8178906]. Mutations in SNORD50 or reduction of its expression have been associated with tumor-suppressor-like behavior in prostate, breast, and colorectal cancers [PMC8677010]. SNORD50 has been identified as a tumor suppressor snoRNA involved in prostate and breast cancer [PMC5503938]. It has also been found to be downregulated in hepatocellular carcinoma (HCC) [PMC7582339]. The genomic location of SNORD50 suggests its potential involvement in malignancies, as it is affected by the recurrent breakpoint t(3;6)(q27;q15) involved in human B-cell lymphoma [PMC8629011]. In prostate cancer, a two-basepair homozygous deletion was found in the genetic locus of SNORD50, and ectopic expression of SNORD50 reduced colony formation [PMC5503938]. In breast cancer, it was also shown to play a tumor-suppressive role by modulating Ras-ERK1/ERK2 signaling via direct binding to the KRAS protein [PMC5552212]. Overall, snoRNAs like SNORD50 have been found to be functionally important in cancer and can function as oncogenes or tumor suppressors [PMC5503938].