SNORA65: SNORA65 is a small nucleolar RNA (snoRNA) that has been implicated in various cancer types, including lung cancer, ameloblastoma, ovarian adenocarcinoma, and oral squamous cell carcinoma (OSCC) [PMC7862062] [PMC5354851]. Depletion of SNORA65 has been shown to impair clonogenic growth of lung cancer cells [PMC7862062]. In addition to SNORA65, other snoRNAs such as SNORA7A and SNORA7B have also been found to be upregulated in tumor tissues [PMC7862062]. The expression levels of SNORA7A, SNORA7B, and SNORA65 are significantly higher in tumor samples compared to normal non-tumor matched controls [PMC7862062]. Furthermore, down-regulation of SNORA65 has been observed in chemo-sensitive ovarian adenocarcinoma compared to chemo-resistant tumors [PMC5354851]. The overexpression of SNORD116-25 and SNORA65 has also been associated with treatment failure in multiple myeloma and ovarian adenocarcinoma [PMC7920560]. Depletion of both SNORA65 and SNORA7A/7B inhibits proliferation and tumorigenicity of lung cancer cells without immediate apoptosis or cell cycle arrest [PMC7862062]. These findings suggest that snoRNAs such as SNORA65 play a crucial role in cancer growth and progression.