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gga-mir-222a: Gga-mir-222a is a microRNA that has been studied in relation to differential expression between two breeds of hens, Hy-line and Lohmann [PMC8390279]. A DEGSeq analysis using the R software environment identified 10 miRNAs that were significantly differentially expressed between the two breeds [PMC8390279]. Among these, gga-mir-222a was one of the miRNAs that showed significantly higher expression levels in Hy-line hens compared to Lohmann hens, with a log2 (fold change) > 1 [PMC8390279]. Additionally, gga-mir-222a was found to have an impact on the concentration of methionine in the medium [PMC8390279]. When gga-mir-222a was added, there was a significant increase (38.71%) in methionine concentration compared to the blank [PMC8390279]. These findings suggest that gga-mir-222a may play a role in regulating gene expression and metabolic processes related to methionine metabolism [PMC8390279]. Further research is needed to fully understand the functional significance of gga-mir-222a and its potential implications for breed-specific differences in hens [PMC8390279].
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