hsa-mir-658: Hsa-mir-658 is a microRNA that has been identified in the colorectal microRNAome and has now been reported in the melanoma microRNAome as well [PMC4516543]. It is one of the miRNAs that is significantly downregulated in melanoma-derived mesenchymal stromal cells (M-MSCs) compared to amniotic fluid MSCs (AF-MSCs), particularly in relation to cell cycle regulation [PMC9319258]. This miRNA has also been found to have a lower abundance in clinical samples of Johne's disease compared to controls and shows statistically significant differential abundance across different experimental cases [PMC7125074]. In breast cancer research, hsa-mir-658 is suggested to function as a molecular sponge, potentially regulating the protein expression of target gene KCNQ4 and influencing cell proliferation and migration [PMC9976483]. Additionally, hsa-mir-658 has been identified as upregulated across various diseases without being downregulated in others, indicating its potential role as a biomarker [PMC4268797]. It also appears to be involved in diverse biological processes given its expression derived from various tissues of origin [PMC3117799] and is among the differentially expressed miRNAs potentially targeted by circ_0001789 [PMC9901162]. Lastly, hsa-mir-658 has been selected as part of an accurate prognostic predictor batch for certain diseases [PMC9241030].