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bta-mir-874: Bta-mir-874 is a downregulated miRNA that is considered a master regulator in the context of immune genes [PMC9445238]. It has been found to potentially regulate the expression of BCL2A1 [PMC7020904]. Additionally, bta-mir-874 has been shown to directly regulate the expression of PPARĪ±, a transcription factor in the PPAR signaling pathway that is involved in lipid metabolism and fat deposition [PMC5341059]. Bta-mir-874 has also been found to have a high number of target genes, indicating its potential regulatory role [PMC6162677]. The alignment and phylogenetic analysis of bta-mir-874 have shown its conservation between cow, mouse, and megabat [PMC8578396]. Furthermore, bta-mir-874 has been associated with fat levels in beef cattle [PMC8578396].
In summary, bta-mir-874 is a downregulated miRNA that plays a role in immune gene regulation and potentially regulates the expression of BCL2A1. It also directly regulates PPARĪ± and is associated with fat levels. The conservation and evolutionary analysis suggest its importance across different species.
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