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hsa-mir-1973: hsa-mir-1973 is a microRNA that has been observed to be upregulated in senescent endothelial cells, suggesting a potential role in cellular aging processes [PMC5295434]. This microRNA, along with hsa-miR-4485, is believed to originate from the ASncmtRNA-2 stem and is processed by the enzyme Dicer [PMC5295434]. Among the microRNAs studied, hsa-mir-1973 showed the most pronounced increase in expression levels during endothelial cell senescence [PMC7027234]. This upregulation contrasts with the expression pattern of hsa-miR-4520-5p, which was found to be significantly decreased in these cells [PMC7027234]. The differential expression of these microRNAs could contribute to understanding the molecular mechanisms underlying endothelial cell aging and senescence.
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