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Homo sapiens (human) long intergenic non-protein coding RNA 1915 (LINC01915) URS000050119D_9606

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LINC01915: LINC01915 is a long non-coding RNA (lncRNA) that has been found to play a role in inhibiting the conversion of normal fibroblasts (NFs) into cancer-associated fibroblasts (CAFs) and angiogenesis, thereby preventing tumor growth [PMC9096125]. It has been reported that LINC01915 inhibits the formation of CAFs through the miR-92a-3p/KLF4/CH25H axis and is downregulated in colorectal cancer (CRC) compared to normal tissues [PMC9286950]. In a study analyzing high-risk lncRNAs (HRLs), LINC01915 was included and found to be downregulated in tumor samples [PMC9286950]. Additionally, low expression of LINC01915 has been associated with poorer overall survival in CRC patients [PMC10093070]. Furthermore, LINC01915 has been shown to inhibit the uptake of CRC-derived extracellular vesicles (EVs) by NFs through the miR-92a-3p/Kruppel-like factor (KLF)4/CH25H axis, thereby preventing angiogenesis and the conversion of NFs into CAFs [PMC10093070]. Overall, these findings suggest that LINC01915 plays a crucial role in inhibiting tumor growth by regulating fibroblast conversion and angiogenesis.

Genome locations

Gene Ontology annotations

Sequence

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AAUCACUAAUGACCUCAUCUUCAAAUGGUCAGUGAUAAUAAACAAGAAGGAGGGAUUUCCAAGGGAGCAGAGCAUUAAUAAGCUACUUGUGCAAGAAGCUACAAUGAGAAAAAAAAUAGCAAGAAAUAGAUGAGGGAAGGAGGUUCUGUAGAGGGAAAAACAAAGAGAGAAAAGGAGAAUGAAUUGUGCUGAGAAAGAGAUGCCUGGAUGAAGAAGCUGGCCCUAGCACCCAUAAAGCUGGAAAGAAAGUGGGGCCUUGGAAACUUCUGGAAGGAUGCGAGGAAAGAAAAAUGCAAGGAAAUGAGAUGGAGAGGAGAAAGAGAAACCAGGAAGCACUUCGGAAGCAUGUAAAUUACAAGGAAAUGAGGAACAGCCUUUAUUGAAACAGUCUGUGAAGUCUGUGCUAGCGCUGAGAGCUUCAUUUUACUGUCCUGGCAAGGAGGUGUGGCCCCUCUCCAGUGCCCAGCACCUCAUCGCUGUGGUAACAGAAGACACGCUUAUCUUCCGGAUUUUGCCUCAGAGACUUGGGCUGUACAAGCUGCUUUCCUGGGGUGGCUUGUCCUUUUGCAGUUAACCGAGAUGCCUGGGGAGAAGAGCUUCCCCCAACAGGAUGGCAGGCGAUGCUUCCAGAUGCGGUCACUUGGCACGUCUGAGCCGAAUGUCUCCAUAAAAAUAUGAUGUAAUUAACAGAGCCGCAGCAGCUGGAACAAUUCAGCACCUCACAUUGAUUUUCCAUGUCUCCUAUUUACUUUCAGUUUUUAAACUGUCUGCAGUGACAGGAAAUCAAAGAAUUAUAAUGGUGUGUGUGAGGGCCCAAUGCUGGGUCGGCAUUUCCUUGUGAAAUCCUGAGAUUAAUCAGUUUCCUAUCACUCAAUCAUCCCUUUUCACUUCUAAAGGAAAACUGUCCUCCCAAAUGCUACGAAAUAGCAGUCUAUUUUUGGAUAUUAAAAAAAUCAAUUGUAUUAUUUUAAAAUUUGAGAGGAGUGUUUUUAAAAAAAGUCAGCCCGAAGCAAUAUUCACUUAUCUGUUUUCCCAUUCAAGUUUAAUAGGAGUUGGCAAAGGCAUUUGGGUGCAGUGAGACACAAGUACUAUAUUCACCCUUCCCAAGUUUUGAGAGCUUGGAAAAGUUACUUGGUGGAACCAAAGAGAGGAACUGCAUUCCAAGUUUUUUUGAUCACUGAAAUGAAGGAAAAUAAGUUUCCCCAUAUGUGGUUAUUCAUGAGCCUUCAUCUGAAGCUGGUGGUUUUCUCAUAGUUGGUCACUGUAUUUCCAGCUCUGUCAGGUGAAAGUCAGAAUCUUGGGUUAAUUUCACUUUGGGUUCCUUAAAAUGCUGGAGAAAAUAGGCAGCUGCGGUUGUAGUGGGGAAACAGGCCUCUGUCUGAAGUCAGCUUGCUCUAGAUUGUGUUUGAAAACAUGCCUCAGAUUUAAGUGGUCUUGCUUUUUUUCCAGACUCCCUUGCCUUGGCAGAUUCUGUGUCUUGGCCAUACUGUAAGAACUCACUUUUCUUUGUCUUUUUAUUGAUUCAAGCAAUAUAACCAUUUCAUAAAUAAUUAGGAAAAUAAAGAAGAAAAUUUCUCAUAAUUCUACUGCUCAAACGCAAUAGCUAUGAUUGCUUUGGAGCAAUUGCUUUGGGUCAUUUUCAAAUGCUGAGUUUUGGUAUGAUUCUAAGCAUAAUGUACAAACAACUUUACAUGUUGCUUUUUCACUUAAUCUAUGUCAGAAGCAUCUCCCCAAGUUAUGAUUAGCUUCAGUAAUUAUCUUUUUAAUUGCUGCCCAAACAGCUGGAACAAUUCAGUCCCUCUUAUUGACUUUCCAUGUGUCCUAUGGAAGUAGAGACAGUCUAUUAACUAUUUCUGUAUUUUGGGACAAUAGAUCAAAUUCAUUUUUCACUGUAAUUAAUCCCAUGAUAAGUAUCUUUAUAAAUAAGCCUUUUCUAUAUAUAAGAUAAUUUCUUUAGGAUAAAUUCCUAGAAAUUACAGGGUCAAAGUGGAUACAUAUUUUAUGACUCUUGAUAUUUCUUAUUGACCUUUAAAGCUAUUAUGUGACUUUAUAUUAUCACCUAAAAUGUUUGAGGAAUUCAUGCUUUACGAGCGUAUUUUAUUGACUAAAUAUGCAGUACUGAGAGAGCUUUAUGUGUGCAGUUUGAUGAUGCUGACAGAUAUCCCGGAGAUAAACAUUUUUUAAUUUAAAGAUGUUCUGUUUAUGUUUAACAUACAGAAGUUAAUGUUAAACAUGAUGCCUAUUUUGUUUAACAUACAGAAGUGACUGUAUUAAAGCCAUUUCUUCUAAAUGUGCAAUAAACUAUGAAUUCUUUGCCUGGU

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Publications