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snora41: SNORA41 is a small nucleolar RNA (snoRNA) of the H/ACA box class, which is involved in the chemical modification of other RNAs, particularly ribosomal RNAs [PMC9110153]. It was found to be up-regulated in olfactory bulb neural stem cells (OBNS) treated with a green fluorescent protein-human nerve growth factor (GFP-hNGF) construct, suggesting a role in neural gene expression [PMC3868548]. SNORA41 expression was down-regulated in the mammary glands of offspring from dams fed a control diet, which was associated with reduced cancer risk and improved immune functions [PMC5494892]. Contrary to downregulation in chronic enteritis, SNORA41 may actually be involved in promoting carcinogenesis and cancer progression [PMC8806983]. In non-small cell lung carcinoma (NSCLC), SNORA41 was among the snoRNAs that were overexpressed and detectable at significantly higher levels in patients' plasma compared to healthy controls or chronic obstructive pulmonary disease (COPD) patients [PMC4913179]. These findings highlight SNORA41's potential as a biomarker for cancer prognosis and its involvement in gene expression modulation related to neural development and immune functions.
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