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rno-mir-1298: miR-1298 is a novel miRNA that inhibits the growth of KRAS-driven cancer cells both in vitro and in vivo [27]. It is down-regulated in gastric cancer tissues and cells, and its over-expression inhibits cell proliferation and invasion [15]. Lower miR-1298 expression levels are associated with lymph node metastasis, TNM stage, and predict poor disease-free survival (DFS) and overall survival (OS) of patients with gastric cancer [15]. It is also down-regulated in neuroglioma [14]. In rat glioma C6 cells, rno-mir-1298 is significantly down-regulated, and its over-expression inhibits proliferation and induces apoptosis [28]. In glioblastoma tissues, miR-1298-5p is decreased, and its over-expression inhibits proliferation, migration, invasion, and induces apoptosis of glioma cells [PMC7367721]. B4galt1 is a target gene of rno-mir-1298 that is negatively regulated by it [PMC9482859]. Rno-mir-1298 expression levels are significantly decreased following DMED (diabetic microvascular endothelial dysfunction) but upregulated with MSCs (mesenchymal stem cells) treatment [PMC9482859]. Rno-mir-1298 expression levels are also significantly downregulated in ischemia-reperfusion models of rat tumor C6 cells but upregulated after apelin-13 reperfusion treatment [PMC5879898].
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