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SNORA80E: SNORA80E is a non-coding RNA belonging to the small nucleolar RNA family [PMC6736983]. It acts as an oncogene, promoting cell proliferation and limiting apoptosis and cancer stem cell (CSC) maintenance [PMC7140444]. Overexpression of SNORA80E in normal bronchial epithelial cells (BEAS-2B) and in the H1299 NSCLC cell line leads to increased cell proliferation and soft agar colony formation [PMC7140444]. Inhibition of SNORA80E through siRNA transfection results in decreased cell proliferation, increased apoptosis, and cleavage of caspase-3 and PARP1 [PMC7140444]. Downregulation of SNORA80E expression is expected to reduce tumor cell proliferation [PMC6736983]. Two studies from the laboratory of Jiang have investigated the role of SNORA80E in lung tumorigenesis [PMC7140444]. In lung cancer tissue samples, SNORA80E is significantly overexpressed compared to healthy donors, along with other snoRNAs such as SNORD78 [PMC7140444]. Furthermore, SNORA80E is highly expressed in tumor-initiating cells (TICs) compared to differentiated lung cancer cells [PMC7140444].
References:
- PMC6736983
- PMC7140444
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