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SNORA8: SNORA8 is a small nucleolar RNA gene that is 137 nucleotides long [PMC6399517]. It is one of the genes that remain linked to splice and/or exonic variants [PMC6399517]. The SNP rs7936247, located in the region of histone modifications and regulated SNORA8 expression, has been associated with gestational diabetes mellitus (GDM) risk [PMC9035465]. SNORA8 has been predicted to be associated with the overall survival of cervical cancer patients [PMC8784813]. It has also been identified as one of the small nucleolar RNA genes that can be used to distinguish patients with cholangiocarcinoma (CCA) and primary sclerosing cholangitis (PSC) [PMC7140677]. SNORA8 belongs to a group of small nucleolar RNAs, including SNORD76, SNORD79, SNORD24, SNORD12B, SNORD68, SNORD11B, ZL11 from C/D snoRNAs and SNORA3, SNORA69, and SNORA31 from H/ACA snoRNAs that are differentially expressed in different conditions or diseases [PMC6294694]. In a study on gene expression in mouse liver cancer cells treated with a chemotherapeutic drug called 5-fluorouracil (5-FU), it was found that snoRNAs including SNORA8 were significantly downregulated or upregulated [PMC9321239]. Additionally, it has been identified as one of the potential biomarkers for the prognosis of kidney renal clear cell carcinoma (KIRC) [PMC9468637]. Furthermore, it has been found to be enriched in extracellular vesicles captured from different cell types [PMC5803193].
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