mmu-mir-712: Mmu-mir-712 is a miRNA located at ITS2 of the mouse rRNA gene (Rn45s) [PMC4969525]. It is considered a typical resident miRNA that does not require specific transcriptional factors or nucleases to exert its functions [PMC4969525]. Mmu-mir-712 has been identified as a negative regulator of tissue inhibitor of metalloproteinase 3 (TIMP3) expression [PMC6468398]. In murine models of atherosclerosis, neutralizing mmu-mir-712 by anti-miR-712 rescues TIMP3 expression and prevents disease progression [PMC6468398]. Mmu-mir-712 has also been reported to play roles in endothelial inflammation and atherosclerosis [PMC4338334]. In DIO mice, mmu-mir-712, along with other miRNAs, was found to be upregulated [PMC4571067]. The binding of mmu-mir-712 might be affected by the ss410758894 polymorphism, with the minor A allele showing less similarity to the miRNA-binding site [PMC3394711]. Mmu-mir-712 is derived from pre-ribosomal RNA by exoribonucleases involved in pre-rRNA maturation [PMC6070170]. It has been shown that mmu-mir-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis [PMC4261535]. The mature forms of mmu-mir-712 are mmu-miR-712-5p and mmu-miR-7123p, but their coding genes' locations are still uncertain and their function unknown [PMC4261535].