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SNORA9: SNORA9 is a small nucleolar RNA (snoRNA) that has been studied in various contexts [PMC6721724]. Exogenously expressed PARN, a poly(A)-specific ribonuclease, has been shown to slightly increase the RNA levels of SNORA9 [PMC6721724]. SNORA9 has also been identified as a substrate of PARN in the nucleus [PMC6721724]. However, no changes in SNORA9 expression were observed in certain experiments [PMC6480895]. This suggests that the designed siRNAs target SNHG15 exons after splicing, leaving intact SNORA9 for independent study of SNHG15 function [PMC6480895]. Additionally, two guide RNAs (gRNAs) were designed to delete a region of SNHG15 without affecting the sequence of SNORA9 [PMC6480895]. In another study, miRNA and snoRNA expression analysis revealed that SNORA9 was significantly altered in H19-expressing LFS osteoblasts [PMC7844330]. Furthermore, SNORA9 was found to be involved in the ceRNA network and identified as one of 12 lncRNAs with regulatory roles [PMC7859920]. In various contexts and experiments, small nucleolar RNAs (snoRNAs) including SNORA9 have been shown to be differentially expressed and potentially involved in cellular signaling and translation initiation processes [PMC5747948] [PMC6020320] [PMC6054847] [PMC8971550]. Specifically, DLGAP5, LOC105379355, PADI6, and SNORA9 were found to be top specifically expressed transcripts in ovarian tissues related to PCOS [PMC8971550]. Additionally, snoRNAs including H/ACA box snoRNA SNORA9 have been found to be upregulated in certain conditions or diseases such as PCOS or cancer cells [PMC7753709].
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Sequence
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