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mmu-mir-511: Mmu-mir-511 is a microRNA that was analyzed using qPCR and specific assays [PMC4551340]. A precursor miRNA expression clone for mmu-mir-511 was obtained from GeneCopoeia, along with a scrambled control clone [PMC4551340]. Pre-miR™ miRNA Precursors for mmu-mir-511 were purchased from Ambion [PMC4551340]. While mmu-mir-511 was not detectable in N2a cells, hsa-miR-511 was expressed in HEK293 cells [PMC4023888]. Taqman microRNA assays were used to detect hsa-miR-511, hsa-miR-4711-3p, or mmu-mir-511 [PMC4023888]. Mmu-mir-511 has a perfect seed match to the mouse 3′UTR, while hsa-miR-511 perfectly matches the human 3′UTR carrying the T allele [PMC4023888]. The seed sequence of mouse mmu-mir-511 differs from hsa-miR-511 at the nucleotide complementary to the SNP position [PMC4023888]. Mmu-mir-511 is regulated by GR dimer transactivation and downregulates TNFR1 expression [PMC8870481].
References:
[PMC4551340] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551340/
[PMC4023888] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023888/
[PMC8870481] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870481/
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