hsa-mir-4784: Hsa-mir-4784 is a microRNA that has been investigated for its potential involvement in SARS-CoV-2 infection. In a study, the loss of hsa-mir-4784 binding to the Wuhan-Hu-1 Spike protein, but not to the Beta, Delta, and Omicron Spike proteins, was found to result in the loss of miRNA-mediated regulation of MAPK13. MAPK13 has been shown to indirectly promote inflammation-associated alveolar tissue damage and is integral for SARS-CoV-2 replication [PMC9721271]. The loss of hsa-mir-4784 binding sites on the S protein in Beta, Delta, and Omicron variants may contribute to their higher replication rates and pathogenesis compared to Wuhan-Hu-1 [PMC9721271]. Hsa-mir-4784 shares the same seed sequence as hsa-miR-3150b-3p and is considered a duplicate miRNA [PMC9721271]. The down-regulation of hsa-mir-4784 has been observed in miRNA microarray studies related to disease progression [PMC4626193] [PMC8005181]. Hsa-mir-4784 has also been found to be bound to hsa_circ_002048 and its down-regulation leads to up-regulation of hsa-miR-422a and hsa-miR3944_3p, inhibiting the expression of AP2M1 [PMC9716081]. In summary, hsa-mir-4784 is a microRNA that may play a role in SARS-CoV2 infection by regulating MAPK13 expression. Its down-regulation has been observed in disease progression studies and it is also involved in circRNA-mediated regulation networks.