SNORA64: SNORA64 is a novel pseudouridine molecule that has been identified in mammals [PMC6984369]. It is a type of small nucleolar RNA (snoRNA) that plays a role in various biological processes. In joint aging, specific changes in snoRNA abundance have been observed, including a decrease in SNORD88 and an increase in SNORD38 [PMC5333149]. Additionally, snoRNAs such as SNORA73 and SNORD23 have shown potential as novel biomarkers for joint aging, while SNORA64, SNORD46, and SNORD116 have been implicated as biomarkers for osteoarthritis (OA) [PMC5333149]. In MCF10A cells, depletion of the DKC1 mRNA has been found to lead to a reduction in the levels of SNORA64, along with SNORA67 and SNORA70 [PMC7760958]. The molecule SNORA64 has been shown to regulate the expression of various genes including RPS2 (ribosomal protein S2), TNPO2 (transportin-2), and CACNB3 (regulatory subunit beta-3 of the voltage-dependent calcium channel) [PMC9454646]. In patients with primary open-angle glaucoma (PEXG), lower expression levels of snoRNAs such as SNORA32, SNORD56, and SNORA64 have been observed compared to control groups [PMC9454646]. Conversely, higher expression levels of snoRNAs likeSNORD58A andSNORA77 have been found in patients with PEXG compared to control groups [PMC9454646]. Overall, these findings highlight the potential role of snoRNAs likeSNORA64 as biomarkers for various conditions such as joint aging and PEXG.