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cel-mir-237: Cel-mir-237 is a microRNA (miRNA) that has been identified as a potential predictor of radioresistance [PMC4247386]. It has been found that loss of cel-mir-237 is associated with radioresistance [PMC5173455]. Additionally, there is a temporal correlation between cel-mir-237 and jun-1 expression post-γ-irradiation [PMC5173455]. Experimental studies have shown that cel-mir-237 can alter radiation sensitivity and downregulate jun-1 levels, which is important for cellular survival post-γ-irradiation [PMC5173455]. The expression profile of cel-mir-237 is inversely correlated with jun-1 expression [PMC5173455]. Both cel-mir-237 and hsa-miR125b have been found to induce radiation sensitivity by targeting and downregulating JUN [PMC5173455]. It has been predicted that jun1 is a target of cel-mir-237 based on sequence and conservation analysis [PMC5173455]. The loss of cel-mir-237 protects cells from γ-radiation, while overexpression of cel-miR 237 promotes radiosensitivity in C. elegans nematodes [PMC5173455]. The levels of cel-miR 237 significantly decrease in wild-type N2 animals after γ-radiation treatment, suggesting an active downregulation mechanism to promote survival during and after γ-radiation exposure [PMC5173455].
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