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SCARNA11: SCARNA11 is a small nucleolar RNA (snoRNA) that has been found to exhibit high stability to physical degradation due to its short size, which prevents breaks and degradation during heat treatment [PMC4822212]. It is one of the stable RNAs, along with 5S rRNA, 18S rRNA, and cyc1, that show minimal degradation [PMC4822212]. SCARNA11 is the only RNA that showed resistance to heat treatment, with its level remaining close to 100% during the entire degradation process [PMC4822212]. The stability of SCARNA11 can be attributed to its short size and potential modified cap structure [PMC4822212]. SCARNA11 has been identified as one of the RNAs associated with Alzheimer's disease (AD) and Asymptomatic Alzheimer's disease (AsymAD) [PMC8069371]. It has also been found to be upregulated following NTHi infection and associated with better outcome in invasive local breast cancer [PMC4659474] [PMC9803687]. Additionally, SCARNA11 has been reported as a potential predictive candidate for invasive local breast cancer therapy response [PMC9803687] [PMC9917053]. In a study on differentially expressed genes (DEGs), SCARNA11 was found to be slightly upregulated in TA samples [PMC9917053].
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