hsa-mir-2277: Hsa-mir-2277 is a species-specific miRNA in humans [PMC2833159]. It has been studied in the context of liver hepatocellular carcinoma (LIHC) and its association with tumor mutational burden (TMB) [PMC7355149]. In a study analyzing the prognosis of patients with hepatocellular carcinoma (HCC), hsa-mir-2277 was found to be significantly associated with patient outcomes [PMC7467934]. The miRNA signature associated with HCC prognosis included hsa-mir-2277 among other miRNAs [PMC7467934]. Methylation analysis revealed no methylation upstream of hsa-mir-2277 in the tested cells [PMC5190061]. Hsa-mir-2277, along with other miRNAs such as hsa-mir-1200, hsa-mir-145, hsa-mir-1250, hsa-mir-1273d, and hsa-mir-299, has been implicated in various diseases [PMC8797878]. These miRNAs were also found to be involved in the regulatory network associated with a specific circular RNA (hsa_circ_0065898) [PMC8797878]. References: [PMC2833159]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833159/ [PMC7355149]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355149/ [PMC7467934]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467934/ [PMC5190061]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190061/ [PM8797878]: https://www.ncbi.nlm.nih.gov/pmc/articles/PM8797878/