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Homo sapiens (human) AQP4 antisense RNA 1 (AQP4-AS1) URS00000BF0FE_9606

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AQP4-AS1: AQP4-AS1 is an antisense RNA that is involved in regulating the expression of AQP4 mRNA. Overexpression of AQP4-AS1 leads to decreased levels of AQP4 mRNA [PMC8850682]. A study found that in vivo-silencing of AQP4-AS1 reduces retinal neurodegeneration and vascular dysfunctions, counteracting retinal capillary degeneration and reduced reactive gliosis [PMC9598326]. Müller cells, which act as intermediaries between neurons and blood vessels, release vasoactive factors in response to neuronal activity [PMC8850682]. Using a co-culture model, researchers investigated the effects of silencing AQP4-AS1 in Müller cells on the function of endothelial cells [PMC8850682].

Genome locations

Gene Ontology annotations

Sequence

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ACUUUCUAGCUGAACACUCAGCUUCAUCCACUCCAGGACAGCUGAGCGUCUGGAUGGUGUCUCACCCUGUUGCCCAGGCUGGAAUACAGUGGCACGAUCCUGGCUCACUGCAAUCUCCAUCUCCCGGGUUCAAGCGAUUCUCCUGCCUCAGCCUCUCAAGUAGCUGGGAUUACAGGGCUUCAGAAGCUGAUGGCAUAGUUAUGAGAGGGGUGAAGACUGCGACUGCAUUUCCAACAGACCCUGAGGACAAUUGGGAAGAAUGCGCUGAAUAUUUUUGAGCAAUUUCUAUAUGAUAAGCAGUUUUUAGGGCAAGUAUAGGUUGCACUGAUCCUGACCUUUUGGCCUGAGGAUGGAAGUCUUCAGUAUCUGUACAACUUUACUCCCAAGAGCUGGUGUAGAAUGAGUUCCUCUGGCCAUGGGAGGAUCGCAGAGGGGCACCUGCCACCAGCAGCCCAGCCUCAGCACUUUUCUCUUCAGCGUCUUCUUCAAGGUAUUUCCAGUUGCCCGCCCUGAACUGUUUCAGAAUGAGGAGGACACCUGGAGGAAUCUACACGUGCAUAGACCAAUUUGCAAAAGAACCUGUGAGCCAACAUUAUUACCUCAGCUGGAAGAAUUAAUAAGCAACACGUUCACCCAAGAAGUAUUUACUGAGCACCUACUAUGUGCAUUAUUUUCUGGUGUUGGGGCUAGGGGGCAAACGACUCUGACAAGUCUCUGUUCUCAAGGCUGGAGUGCAGCGGCGCGAUCUCGGCUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCGAGUAGCUGGGACUACAGGCGCCCGCAACCACGCCCGGCUAAUUUUUUGUAUUUUUAGUAGAGAUGGGGUUUCACCAUGUUAGUCAGGAUGGUCUCGAUUUCCUGACCUUGUGAUCCGCCCGCCCCCGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCCACCGCGCCCGGCCGUAGUUUACAUUUUCUAAAGCGUACUCUGCCAGCCAAGUGGCAAACAGACUUGGGCCUCUUAAGAGUGGAAGCAGGAGGAAACCCGAAGAUCCUGGAGAGAGACUGGUGGCUGGUACCAGUGGAGAGGGAGCAAAAAGGAAAAUACAGGAUACAAUUUCAGGAAAAAUUUCAUACCAAUUUCCUGAGGUAAUUUCUGAACUCGAACAUUUUCAGUGUCACCACAUUGUGUUUCCUGCUGAAUCAAGUCUACAUCACUUCGGUUUUUAAAGCCUUCCACGAUCCUUCCCUGAACACUGUAGUUUUCACUGAUGGUUGGCUGUUUCAAACUCCCAUAUGAUCCAUACUGUAUCAUUAAUAAGCAAGCAAGGAAUAACACACCCUCUGCUAUUCUGUGCAGUGUUUCAGGUUUUUAGUUUUCUCUUUCAAGAUAGAAAAUCCCUUUAGAGUAGGAACUCGGCUGGCACUUUCUUUCACAUCCUGCAUAGCACUUAGCAAAGUUCUGUACACAGGGCACAUGUGGAAAUUGCUUAUUGAUUGAUUAAAAGCAUAUAUCACUGGCAUUUGUAUCUUCAGUAUUUCUCUUGUAUGAAGAAGGGUGAUUAUCUGUCAAUAUUCAUUGCAUCAUUGAACCAAUGUACAAUGCAUUAAUCAUCACUGAAGAUAACCAGAUGAGGCUUUAUUGUAAUCUCCUUCUAUUUUGCUGAGAUAAUUUCACUUGCUUUAGAGUUUAUGAGGCCAUAAGUGGCUCCCAUCUGUUGAUGAACAUAUUUCUAAGAGUCAUUUAGUCUCAAGUAUGGAAUACUUGAGGGGAAGUUAAAUUGUAACUUUUAUAUUAAGUGUCAUCUUAGUAACAGAACCAAAAUUGGAAGCAUGUGUUCAAUUUUGGUUUUUCAUUUUCAAAGCUUUAGGUCAGGCAAAGAAUUAAUUUCAUUUGUUUACAAAGUAGAUUAUGCCUAAUAAAAUCUAUUUUGUUUAUGGUCACAUUUUAAUCAAUCCACUGCUUUAGAAAAUGAGAGAAUUCUGAUUGGCUAAUCAUUCAACAUAGUAAAUUACAUUAUUCCACAUCCACAGAACACUGGCCUAAUUGCAUUAUCCAGUAAUGAUAAAAAUAUUCCUUUUAAUACAUUUUGAGCAAGGCAUAUACCAGUGAUGAAACAGGGAAGAAUCUUGUUUAUUCCAUCCUUGUUUGAUGAUCGACCACAGAAUAUAACAUAACACUUCUGUGUAUAAGAAUUUUUUCAACAUUAAGGAUAAUAAGGACAAGGUAGUUUUCACUGGAUCCUUACUGGUACUCUGAAUUUUCACUAUUUGUCCGCAUUUCUUCUCCUUCCCGGAAAUUUGUUUUCUGCGAAAAACAAGUGCUACUUUGUCAAAUAAAGCUUAAAUAAAAUUGGUUUCAAUUUAUGCAUAAU

Taxonomic tree

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Publications