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SNORD56: SNORD56 is a snoRNA that has been studied in various contexts. It has been shown that the expression of wild-type DDX21 rescues the recruitment defects of SNORD56 in cells depleted of endogenous DDX21, while expression of inactive DDX21SAT does not [PMC4288182]. In chronic lymphocytic leukemia (CLL), several snoRNAs, including SNORA31, SNORA6, SNORA62, and SNORA71C, are down-regulated. These snoRNAs are involved in the pseudouridineization of rRNA and their host genes have roles in tumor-related signal transduction [PMC4288182]. Upregulated expression of SNORD116-18, SNORA70F, SNORA74A, SNORD56, and SNORD1A is associated with shorter progression-free survival (PFS) in CLL patients. The functions of these snoRNAs are not well understood but they have been suggested to be involved in the regulation of alternative splicing [PMC8975097]. In CLL cells induced to proliferate, 7 snoRNAs continue to be up-regulated while 2 snoRNAs (SNORA80 and SNORD1A) are down-regulated [PMC8975097]. The regulation of snoRNAs during CLL cell proliferation is complex [PMC8975097]. Additionally, interactions between snoRD16 and SNORD56 may contribute to the regulation of C517 methylation [PMC5612246]. In a study comparing cataract and PEXG groups, lower expression levels were observed for five out of seven snoRNAs including SNORD56 in the PEXG group [PMC9454646]. Overall, these findings highlight the diverse roles and complex regulation mechanisms associated with SnoRD56.
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