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Homo sapiens (human) long intergenic non-protein coding RNA 1278 (LINC01278) URS0000CCE138_9606

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LINC01278: LINC01278 is a long non-coding RNA (lncRNA) that has been found to inhibit UM (uveal melanoma) formation by promoting autophagy [PMC9876672]. Upregulation of LINC01278 is frequently associated with a worse prognosis [PMC8959654]. Through analysis of the ENCORI database, it has been revealed that LINC01278, along with another lncRNA called AC021092.1, are upstream molecules of miR-185-5p [PMC9050325]. It has been speculated that the promoter of LINC01278 may contain a Smad responsive element (SRE) [PMC7269911]. Additionally, there is evidence indicating an interaction between LINC01278 and β-catenin [PMC8285859]. In the context of vascular smooth muscle cells (VSMCs), the expression of LINC01278, miR‐500b‐5p, and ACTG2 were measured to investigate the role of LINC01278 in VSMC proliferation regulation [PMC8200748]. Furthermore, it has been suggested that LINC01278 may play a role in hepatocellular carcinoma (HCC) metastasis by mediating the Wnt/β-catenin and TGF-β/Smad pathways [PMC9716033]. LINC01278 has also been implicated in osteosarcoma (OS) growth by acting as a sponge for miR-134-5p to regulate KRAS expression [PMC7847385]. Additionally, there is evidence indicating reciprocal regulation between miR-1258 and the expression of LINC01278 [PMC7269911]. In summary, LINC01278 is an lncRNA that can inhibit UM formation and its upregulation is associated with worse prognosis. It interacts with various molecules and pathways in different contexts such as VSMC proliferation, HCC metastasis, and OS growth. The reciprocal regulation between LINC01278 and miR-1258 has also been observed.

Genome locations

Gene Ontology annotations

Sequence

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AUUGCCUGGGAAACUAAGUCACGUGAGAACCUGGGGACGCUAGGUUCCGGAACCUGACCUGAGCUGGGGCCUGUGCUUCCAGCGGGUGGUGGGGGGCCUGGUGUGCUGGCAUCAAGUAAGCCGACUACCUCGGCAAAGGCUUAGGGACAAGAGACCAGCAGCCUGAACUGGCUGGGGCAUCCGGAAGGCUUAGAUCUUGUGGCCAAGAGUUCAGACCGUGGCGAAGUGGAGAGUGACAUGCAGUUGGAUGGCGGUGACUGCGUGGUAUGGAAGAAAAUUCAGCUGAAAUUUGCUAGAAAAUGAGUUGUUUUGGAAAGAGACUGUAGAGAAAGGCAAAUGGAAGAAGAAAGCUUCUGUGCCCCCACAGAUACCGACUGAAAAGUGUUAGCAUGAGCAAAAGUUCCUAUCUAAUAUUAUAUGCUUUCCUUUGCUCCCAGGUCCUGCAACCCUGGUUCCAGUCUGGCAAGCAUUGUAGACCUGGCUGCUGAAGACUGACGGGGCCCAGGGUCCGCUGCCCCCACCGCCAUCACCACCUCGGAACCCAGGGUAACGCUGUCAGUCUUUGGACCAACCUCGCUGUGCCUAACAAGAAUUCCAGAAGUCACCCAUCCGAAAGGCACUGGCCCAUGACACUCUCCACUUCCAAUCUUAAAUCUUUUACUUCAUACCUUGUCUCAGAUCUCUCCUGGUACCCCUUCCCCACGCCCUUAGAUAAUCCAUCUCAAUUCCUCAUGCUAAUUGAGGAGCUAUGGCUGCAAGGCACCUUCCAGGAUUUCACACCUACACAAAUCUCCUUUUUCUCCUUUUGCCUUCUCUGCUUAUGGGAUAUUCUGAGUCCCCACCCCCAAUCACUGACAGCUGGGCCCCCUUCAUCAGCCUCACACACCACGUAUUAAGUCAGUCACAAUCUCCCCUCUCCUCUAACUGCUGGAUUUGUCUUUCUACACACACCCAAUGAUUCACGGCUCUUCCGGCUGACCUACUUACAUGGACACAGUCCAACGUGAGCUUACACAUUUCUUACUUGGCUAUACCAUUCUUGGCUGAUUCAUUCCUGAAACCGGUUCAUAACCUGGAAACUCAGCUAAACACCUUUCCUUCAAACUCAGCUCUCUCAGCAUGGUUUCAGGUAGGGCUGUUGCCCUCCUUCACCUAAUAGCUUCUGGACUAACAUCCAUACAAACCAACACAGCAUCAUCUAAACCACCAAUAUGGGGGUACCAUUUCUACUCAAACUUCCUUCAUAUCCCCACCCCCCUUAUGUCUCAGCCGAACCUACCCUAAUCCAGCCCACGCCACAAUGGUGGGACAGGUUCCCCAGUCCCUAUGUGGUCUUAUUUUUACCCUUGCACUCCCUGUAGACCAUCAAUUCUACACCCUAAUUACAAAAUCAUAUCCACCUCUGCCUGGCAGAAGGUGUUAUGCUUUUCUGGCUCGCCUACCAUCCACACAUCCCUACACCUCACCACCGGAUCCUCUUUUCUUUCCUUCCAUCCAAUUCCUGGCUUCCCCGCUGCCAACUCUGCUCUCUAUGUCUCCAGUUUAAAGGUGCCCCCUGGAAAAAAUGUAACAAUUCCCUCACCUGUGACUGGUACCUGACAGCCACCACACCGGGGCAGCAAUGGCUAACGGUUGACAAAGACAAUUUCUUUCUCUCUCCAAAACCAAACAGCCUUCAUCAACUCCCUAGCCAAGACUCCCUAUCAGGCCCUUACAGGUGCCGCUCUGGCUGGCAGUUACCCAAUUUGGGAAAACGAAAAUACCCUAUCAUGGCUACCUACCUUCACCUACAACUUCUGCCUGUCCACCCCCAGUCUCUUCUUUUUGUGUGAUACAAACUGAUAUCUUUGCCUACCAGCCAACUGGUCAGGAACUUGCACCCUGGUCUUUCAGGCUCCAACCAUCAACAUCCUACCCCCUAACCAAACUAUUCUAAUUUCUGUAGAAGCCUCUAUCUCCUCUUCACCCAUAAGAAAUAAAUGGGCUCUACAUCUCAUCACCCUGCUAACAGGAUUAGGCAUCACUGCUGCACUUGGCACUGGAAUAGCAGGCAUAACCACCUCAAUCACCUCAUACCAAACACUAUUCACAACCCUUUCUAACACCGUAGAAGAUAUGCACACUUCCAUUACCAGUCUCCAACGACAAUUAGACUUCCUCGUGGGAGUCAUCCUUCAAAACUGGAGAGUCCUGGACCUCCUAACCACUGAGAAAGGGGGUACCUGCAUAUACCUCCAGGAAGAAUGCUGUUUCUGUGUUAAUGAAUCUGGCAUUGUUCAUAUCGCAGUUCGUAGGCUUCAUGACAGGGCUGCAGAGCUUUGACAUCAAGUCGCUGACUCCUGGUGGCAAGGAUCAUCCCUUCUAAGAUGGAUACCCUGGGUUGCCCCCUUCCUAGGACCCCUGAUCUUCCUCUUCCUGUUACUAAUGAUUGGGCCAUGCAUAUUUAACCUUGUAUCCCGCUUCAUUUCCCAAAGGCUGAAUUGUUUUAUCCAGGCAAGCAUGCAAAAACACAUUGAUAAUAUAUUUCACCUUUGCCACGUCUAAUACCAGAGCCUACGAGGAAACCAUUCGGAAGCUCCAGAACCCAGGCCCUAAUCACAACGCCCCUAUCCAGCAGGAAGCAGCCAGAUGAUCAACGACGCCCUUUUUCCUUUUUAUACUAAAGUAAGAAAUAAGAAUGUUAGCCCAAACUGCACUAUUUUGCAGACCCCUACCAUUUUACAAACUGGUCAGAGUGGAAAAUUCCACCAGGGCCUGAGCUGUGAGAAACAUCCUGUCAGGCAGGUCCCAGGCCUAACCCCUGGCUGCACUAAAUUCCUUCAUUAUCAGCAGCCAAACACACCGCCCCCACCCCAUUUUCACAACAAUCCCAGACCUCUCCUGCCCGGGACUGUAACUGGUCCAGCCUGUAAGCGGGAAGGGGGCUCUGGCACUAGCUGGUACCCCCUCUCCGCAGGUCUUUCUCCCAAUAAAUCUGUGUUGCCAUUGAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications