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Homo sapiens (human) MIR31 host gene (MIR31HG) URS0000CCDFB4_9606

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MIR31HG: MIR31HG is a long non-coding RNA (lncRNA) that has been the focus of rare research in various diseases, including thyroid cancer, pancreatic ductal adenocarcinoma (PDAC), lung cancer, psoriasis, and colorectal cancer [PMC9440494] [PMC9022350] [PMC10132190] [PMC6122774] [PMC9428519]. Studies have shown that MIR31HG can regulate adipocyte differentiation and histone modifications of the FABP4 promoter [PMC9535873]. It has also been found to be upregulated in PDAC and can inhibit oncogene-induced cell senescence by regulating the transcription of tumor suppressor p16 (INK4A) [PMC6247607]. MIR31HG is involved in osteogenic differentiation and can downregulate lncRNA brain-derived neurotrophic factor-antisense transcript (BDNF-AS) expression [PMC7137347]. Additionally, MIR31HG has been shown to regulate the TGFβ-induced epithelial-mesenchymal transition (EMT) process and cell invasion in non-small cell lung cancer (NSCLC) [PMC9223781] [PMC6313218]. It also plays a role in the EGFR/PI3K/AKT signaling pathway and affects cell proliferation and sensitivity to gefitinib in NSCLC cells [PMC9757018]. Furthermore, MIR31HG has been associated with tumor invasion, angiogenesis, poor prognosis, and disease-free survival in various cancers including lung adenocarcinoma (LAD), osteosarcoma (OS), gastrointestinal cancer, head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma (HCC), breast cancer, basal subtype tumors with worse overall survival (OS), as well as colorectal cancer with poor prognosis or risk of recurrence [PMC8080841] [PMC6722458] [PMC6247607] [PMC7745499] [PMC9353736] [PMC7427971]. MIR31HG has also been found to interact with miRNAs, such as miR-193b and miR-361-3p, and regulate their expression and function [PMC4947634]. The haplotype of the MIR31HG gene has also been analyzed in certain studies [PMC9731210].

Genome locations

Gene Ontology annotations

Sequence

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ACUCCCGCGCGCCCCUCUCGGGGACCAGGGCGGCCUCCCAGGAGGAGCUUGGUGAGCAGCUGCGACCUGUGCAUAACUUGGGGCGCCGCCAGGGGCUCGCAGGUUCCACGUCCGGCGCCUGGAGAAGGAAGACGCGCGUCCCCGGCCGCGGCGCCGAAGCCGGCUGGGGGACCGCCUGGUCCCGGGCCAGAGCUGGGAGGCGGUGUUCCGUGAGCCGCCUGGUCUGGGGUGCGGGGGGCGGGAAGCGGCCCCUUCGUGUGCGCUUGGGCGAGGCCGGGCGGCGCUUCUGUCCUCCUACUCGGACCCGCAGGUUUCUGGUCCUCAUACCGUGUGGUUGAGUGAAAUCAAAACUUCCACGAUAGCAAUGCUGAUUGGACAAAGAAUGUGUUGUGGACACAAAACCAAACUCUGGAGGACAGAGGAUUCAUUCCAAGGGUCUGCUUGUAUUCAAUGACUGGUCUACGUGGGGGUGUGAAGUCCCCUUACUCCACCUGUGAAGAGUCUUCCCAGUUUCAGACCACCCUCCCAGCCUCCUGUUAUUGGCUAAGGCCAUUUUGUGACUACACUGCAGGUAGAGAUGGAUUCCUGGAAAUACCUCCUCAAGGCCAGUGUAGAGCCCUCAAUCACCCACUGCCCCCAGCUUCUCCUUCUCCCAUCUCCUGCACCAAGCAGGUCUCCAGGUGUUCCAGCUGCUGAUGACGUAAAGUGUGGAGUUGGUCCAGGAAGGUCAUGUUCCAUGCAGCAGAGGAGCGCUUUGUGUGAGAAGUUGAAGACCUGCUGUAACACAUCAUAGAGGAAAGACAUAGCCUGGGCCUUCUGCAACUGGCUGACUUCCACCUUCUCCUGGGGGAAUCUGAAGUCACUUCUGUCCUUUAGACACAAGAAGGGAGAGAUUCUCCUCAUUUGGCCCAAAAGCACCAAGGUGUUCCUGCCUAGCAGGCCAUGGUUCUGAGGCAGGUUAUAUCCUAGAGAUCCAGAAGAGCCACAGCUGCACACCUCUAGGGCUGCCAGUAGAGGGAAGAGGAGGGCCAUUGAGAAAUCAGGAUGCUUUUGGCCUGGUUGAGCUGAGGUCUUCAUAGAACCUUGGAUCCUAGGUUCUAUGAAGACAUUCUAUCUAUGCAUGGCUUUAAUGGAGCACAAAUAGUUUUCAUUUUUCUGAGCAUUUCUCUAAAUUUUUAAUUCCAUUUAUUGUUUUCAUUUACAUGUCUUCUAUAUCAGCAUCCACAACCUUUUGGCCACCAGUUUGGUGGAAGAUAAUUUUUCCACGAAAAAUGGGGUCAGGGAGGGAAUGCUUUCAGAGGCAUUAGAUUCUCAUUAGGAGACCACAACCUAGAUCCUUCGCAUCUGCACUUCACAAUAGGGUUCCUGCUCUUUUGAGAAUCCAAUGCCACUGCUGAUCUGACAGGAGGCAGAGCUCAGGCGUUAAUGCUUGUUGGUUGGCCUGCUUGCCUCCUGCUGUGCGGCCCUGUUCCUACCAGGCCAGGACCAGUACCCCGGUCCAUGGAUGGGGGUUGAAAAACCUUGUUCUAUAUGACCUAAAAGGAGGUCAUCACUCUACACUCUUGAUUUUUGCAAUGGAUGUUCAAUAUUCCCAGUAAACUUAAGAUAUAUCAAUCCAAAUGAAUAUUGAUCAAUCAGAUGAGAAACAUCUUUGUGCUACUGUUAGAAGUAUAUACUUUUAGCCCAGAUCCUAGCCUCCAGUUUUACCCUCCAUUUUGCAUAGGAAAUCAGGAUCCCUGGGCCCUAUGGGUUUCUGUAUUCAGUUAGGAAAUUACCUAUCUCUGGAAAUUAAACUUUUUAGGACUAUCUUUGUUUGAUAUUUGAUUCACAGAAGACGUUGAUGGUUAUUAGUGAAAGAACUUCUCUGGUGCUUCCCUCCUUCUAGAAUAUAUUCAUUCAGGUUCAUGUGGUUAUGCUUCCCUGGGGGCUCAAGCUUAGAUCAAUGAACAUUGCCUUUUUUGCAUUAUUUUCUUACUGGAGAAAUAUAGCACUCCUCAGGCUGCGCCAAUACCCCUAAAAGAAAUUCUGUUGGUUUGUUUUUUUUUCUUUUUUAAGAUGCAUAUGGGUGUGGAAAUUUUAAUCUUAAAAUAAUGUUAUUUCCUCAGCAGUGAUGAUUCACAAGGUAUUUAUCACAUCAAGUCACUCCCUAAAUGCAGGCUCACCACAUCCUGAUGACUUUAGAACUCCUUUUCCAGGGAGGUUCUUGCUUCUUUGUUGCCAAAACAAUAAAUCCUUUGUGACCUUUGUCAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications