Homo sapiens (human) disrupted in renal carcinoma 3 (DIRC3)

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Homo sapiens (human) disrupted in renal carcinoma 3 (DIRC3) URS0000CCDF88_9606

3,910 nucleotides
4 databases (GeneCards, HGNC, MalaCards, RefSeq)
Found in 0 other species
86 publications
lncRNA

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DIRC3: DIRC3 is a gene that is associated with melanoma and has been found to contain three sites of MITF-SOX10 co-occupancy in melanoma cells [PMC6934268]. The expressions of several genes, including Linc0116, Linc00667, CDK6-AS1, FENDRR, and DIRC3, were found to be similar between affected and unaffected tissues but significantly lower in the blood samples of patients compared to control samples [PMC8466695]. In genome-wide association studies (GWAS) conducted in European and Korean populations, DIRC3 was identified as a common genetic locus associated with susceptibility to melanoma [PMC6021314]. The DIRC3 locus was found to be connected to the IGFBP5 promoter through two DNA looping interactions [PMC9453429]. Reduction of DIRC3 expression was shown to increase melanoma cell colony formation in soft agar [PMC6934268]. Further investigation revealed that DIRC3 inhibits the proliferation of melanoma cells by increasing the expression of the tumor suppressor IGFBP5 [PMC8564738]. In summary, DIRC3 is a gene associated with melanoma that has been shown to have co-occupancy sites with MITF-SOX10 and plays a role in inhibiting cell proliferation through its interaction with IGFBP5.

Genome locations

Gene Ontology annotations

Sequence

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AGAGCCCAGCGUGCGCGGCCUUGCGUGCGUGCACACGCAUAUGUGUCCAGGUGCCUACGCAGGUGCCUGACCCUGGGCAAGUCGCUCCGUCAUGCGGACCUCAGUUUUCUCAUCUGUCCGACGAAGCAUGAUUUUCUGGUCAGACUGCAUCAGCUCCCUCUUCUCCACCAGGACAGUAGGGAUCUACAGCCCAAGAACCAAAGACUUUGGACAUUUUGUUCUACUUGGGAAGUUUGUAAUGUUAUCUUCUGCUGUGGAGCAUAGUGCAAAGAAAUAGGGGGAAGAAAGGUGGGUUUCUUCUGUCUCCACCCCAAAGACCAAGGAUACUUUCUUCCCUGAGGGUUGCCUCUGCAUUGCAAGUUUUUUCUGACCCUUCACUACACAGAUGGACAACUCAGGUGGCCAGAGGACUUCAACUGAAUGGAAUUACACAAUGAUUUGUUGAACAUGUAUUGUGCACCAGGGAGUAUGUGAGGCUAUGUGGUAGGCAUGAGAUGAACAAUGGAAGAUUCUUGCCCCAUGGAAGGUGACCACUGGAAUUAGAAAUCCUAGCAUCACCUAAGGAAAGGCUCAGAUCUUCCCUGGUGGAGGUUGGGGAUCUUCCCGAAGGGACCUUUUGGACCCAGAGCUCUUGUAUCAUUGCCUCUUGGCAAGAGGUUUAGAGACUCCCUUCAUCAUGAAGUUUCACAGACUCCUUCAGCCUUUAUCUUUCCUGAGUUCUAUGGGGAAAAGCUAGGUUAGAUAUGUGGAGUGACUCACCGAGACCUGAGAAGGCAUCUGCAUGAGGCUGCGGGGGUGUCCUUAGAGAAAAGGGAAGCUGCAGUGUGGAGGCUGGGGGAUGCACAAGAUGAUCUCCAGAGUCUCUCAGCCUUCAGAAGCGCAGGCUCUCUGAGGCCACAUUCCUUCCUGGUCUGGCUCAGUGGAGGCUGUGUUUCCCCACUGUUGCUUUUUGCAUGGAUUUGUUCAGCAGUUGAAUGGGCAGAGAAGGAGGAGUCUCUCCCUUCCUGUUCUCACACAGCUCUGCUUCAUGGACACCCACACAGAUUCACUGGAGAGCAAAGCCUACCAGAGUCCCUGUCAGCAGCACUGUUUCUAGAAGCUUCCACAUGAGCAGACAGCAUGGAGUCCUGGGGGCUAAUGAAGCAGCAAUGUCAGCAUGAGCACAGGCAGGGAGAGGCAAGAGGAGCAGAGUAAAGGGGAACGUUCUCUUCAUUCUUCCACCUGCCUGUCCCCCAGCCGACACGUCCCUUCCGUUCCCUGCAAGGCCAUUUCCAGGGAGGCUUACGAAGACAGCAGAUGAUGGUGAUGGAAGGAGUCUGGGUGCUGAGCUGUGCCAUGGACCUGGAGAGAAACUGAGUCCGAGGGAUGUCAACAUGCCAAGUCCAUGGAAAUAUCAGUGGGCUGGAAUUCUAGCUGCCUGAAAGAAGACAUUCCUCACACAAGACCUCACAAUCAUAUCCAUGGAAUUAUAGCACUGGGCUCUCCAGAUGGUGCUACAGGAAGACCUCCAGAAAUUUGACAAUCCUCUAUUCAAGGCCCUACCACAGAGACACACAGGAACGGAACUCAGAAUCACAAACAAAGAAACUUUGAUCCAAGAAAGAAAAUGAUCUUUAAAAAGACCCUCGUUUCAUGCUGGCCGAUGCUGAGAAAAUCUGCUCUGAAGGAUAUUUGGAGACACUGAUUAAAAGAUGGUUGUCCCAGUGGAGGGGGAUUCUUCGUGUUACGUAGAUAGGAAGCACGAUGCAAAAGUGUUGAAGCAGGAGUGUAAAGAAUAAUUAAAACACCUGCCCAAGACCCAAGCAAGGAUAGGAUUUCCCAGACAUUCGUGAGGGAGAAAAUGCCAUGUCCUUUCCUUCUGGUGUCACAUCAGAAUCUGAAGGCUGCUAGAGAAGGGAGAGAAACAUGAAAGUGAGUCCCAUGCUGAUUGUUGUUGAAAUACCUGGAAAGAAACUGGCAAAGACUAUCCAAGGGAUGCUAAGACAUGUCCGAACUUACAAAACAGUAGAACCUGAAUAGGAAUUUGAAGUUGUCUAUACUCUCCUCAGCCACACCCUGCCAUUUUACAGAUUGUCUUCUCUGGGGAAGUUAGCUGUCAUGUUGUGAGGAUACUCAAGCAGUUUAUAAAGAGGUUCAUGUCGCAAGGAAUGGAGGCCUCCUGCCAACAGCCAUGUAAAGGAGCCAUCUAGGAAAUAGAUUCUCCAGCCCCAGUCAGACCUUCAGAUGAUUACAGCCCCUACCAACCUUCUGACUGCGGUGGAAGGAAGGUUCCGGAACCAGAACCACCCAGGUUAAUGUGGGUAAGUCUCAUCCAAUCCUUUGAAGGCCUGAAGAACAAAGAGUGAGGUUUCUGGAAGAAGAAAAUUUUACCUCAAGCCUGCAAUGUAGAAAUUCUGCUUGAGUUUCCCGCCUGCUGGCCUGCCCUGUGGAAUUCGGAGUCAAGAAGGAGUCUUGUAAGCAUUAACUGAGAUAGUAUAUGAAGAGUGCUUUUGCACCGAGUGAACCUUCAAUCAACUGUACUAGUUUGUAUGCCUGGAAGAGCUGCUAUAUGGGAUCAGAAAGAAAAAUAAGGUGCAUACGCCAGAAAAAAAAUACUUGCAUAUGAGUACUAGGAGAUGCAUGACAAUGUUCACGGCAGCAGUAUUCAUGGCAGUGAAAAAUGAAAAGAACUGAAAUGCCCAUUGAUAAAAACGUCUACUUAUUUGUGUCAUCUUUGCACAGUGGAAUUGUGCGAGUGGAAAUGAUUGAUCUACAGCUAGGAGAAGCAGCAGAGCUCAAUCUCAAAAACAUAACGUUGUGUGGAAAAAGCUAACCUCAGAACACUUUGCGGCUCUAUCUUAGCAAACCAGGAGAGAAAUUCUCCUGAUGGCCUUGAAGAAGCAAACAGCCACCUGGUUAAGCCCCUGUGGAUAGUGCCAAGUGGCAGGAAAGUGGGAGCCACCUCUAGGACCUGAGGAUUAAAGUCAGUAAGAGCUGGGACCUCACUCAUGCAGACUCGAGGACAUGAAUUCGACCAACAACUUGAAUGAGCUUGGAAGUGGAUUCUUCCCUAGUCCAGUCUUCAGAAAUUAAGAAUGUUCCCAAAGAAUGAUGGAGACAUUUCAAAAGGAUACGGAAGCCAGAUUGUGGGCGCUUCUACUGGCCAACUCUGGGACAUCGUGGACAUCAAAAUAAAUUUGUAAUAAUAAAGGAUUAUAGCCUAUUAGUUAAAUCAGAAAAAUCUGAUUUAACUAAAUGAGUAGGAGGAAAAGAAAGCUCUUCCUUAUAUUAGAAAGUCAAUUAAUAAAUGCAGAAAGGAAUGAAAAAAUUAGAAAAGCCACCAUUUGGCAACCAUGGCAGGCAGAAUGGGGAGUAUGCCUCCAGACAGUAAUUCCUUUCAAACUGGUUUAUAGGAACUCACUGAGCUUGCUGAUCGACCUCUGAGAGGCAAAGUUUCUGAAUUAUGAAGUACUGAUUAUAUAAACUUAGACAGAGACAUGCUUCAUUAUUUAAUAGGACUGUGUCAAAAGCCUACUAUUAGGAUGAUGUGUUGGGUGUGGAACAGGGUCUCUUCCUGCCAGGAACACUGGUGAUUUCACUCCGUGUUCAGGCUGAUCUUUGAAGUUGAAGACAAGCAGAAGAAUCCUUCUAAAAUUUAGCCAUGCCCAUAGGCUGGGAGGGACACUGCUCCAUUCAGAGGCAGCAAAGCACAUUACUGUAUCUCCUAUAGAGCUUUGAGCAGUCCAGUGUACAUGGAGAAACUUAGUAAAUGUUGUUGAAUUAGUGAAUGAACAAAUCAAUGGACCAAGUCAGGGGUAAGUCUUACAUUUGUCAUCUAGGUGAUUAAGAAAGGAAAAAGUAUCUGUUUCAAGAGGAUUACAAUCUAACUGUACUCCAAUAGUAAAAUUUACUCUUUUGGAAUCUGAAGACA

Taxonomic tree

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Publications