FLICR: FLICR is a long non-coding RNA (lncRNA) that has been found to be significantly elevated in multiple sclerosis (MS) patients compared to controls [PMC9461285]. Additionally, FLICR has been shown to inhibit the expression of Foxp3, a transcription factor involved in the development and function of regulatory T cells (Treg cells) [PMC8954347]. This inhibition of Foxp3 by FLICR leads to the suppression of Treg cells by modifying chromatin accessibility [PMC8954347]. The elevated expression levels of FLICR in MS patients suggest a potential role for this lncRNA in the pathogenesis of MS [PMC9461285]. The suppression of Treg cells by FLICR may contribute to the dysregulation of immune responses observed in MS patients, as Treg cells play a crucial role in maintaining immune tolerance and preventing autoimmune diseases [PMC8954347]. Further research is needed to fully understand the mechanisms by which FLICR affects Foxp3 expression and Treg cell function, as well as its potential as a therapeutic target for MS.