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Homo sapiens (human) PDX1 associated lncRNA, upregulator of transcription (PLUT) URS0000ABD8D4_9606

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PLUT: PLUT (PDX1-AS1) is a long non-coding RNA (lncRNA) located on 13q12.2, along with the PDX1 gene, as well as KLF5 and KLF12 on 13q22.2, and GP2 on 16p12.3 [PMC7314803]. PLUT has been subcloned into a doxycycline-inducible expression lentiviral vector with an N-terminal Flag tag [PMC8196033]. PLUT has been shown to upregulate the transcription of PDX1 by affecting local 3D chromatin structure [Akerman et al, 2017]. Additionally, PLUT is categorized as a lncRNA that exhibits cis regulation of neighboring protein-coding loci [Chen, 2016]. In terms of trans regulation, PLUT has not been specifically mentioned in the given context. However, other lncRNAs have been reported to regulate gene expression in trans [PMC7073466]. Furthermore, PLUT has been used as a backbone in the subcloning of ARL2-HA and ARL2-Q70L-HA into a doxycycline-inducible promoter system for stable cell subline generation [PMC6240099]. Although not directly mentioned in the given context, lnc13 is another significant lncRNA that regulates human pancreatic β-cell inflammation by allele-specific stabilization of STAT1 mRNA in type 1 diabetes mellitus (T1DM) [PMC8800623].

Genome locations

Gene Ontology annotations

Sequence

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UGUGGACAGUGAAAAAGUCGUUUAUUAGCUGGACGUCCUGAUAGUCCUCGCUGAUACUGGAGGUCCUUGCCGGCCCUCUUCCCCCUUUCCCUUCACAGAGACGCGGUUUACACCCGGGAGAACACAGGUUACCUUGUUCUUGCUGGACCUUCCACAAGUGUUUGCACAUGACCUGGAAGACAGUCAGAGGCAGAAGUCCCUGCAAAUGCUCCUGGCUACUUCCUGCAGGCAGCUCAUGCUGCUGCAGCAGAAGACUUUCCUAUGUCUAGCUGCCAGUAUUCUGGGUGCUGGGGGCAUCCUGUUCCUAGGAUCACAGCCAUGGUGGUAUGUUCUAGAACUCAGAAAUUUACCAAAUCACUGGAUGGACCAGAGGAGUGAGCUCCAGGUUGGGUUUCCAGAAGGGACUCCCAGAACUCUUCCACCAUACAGGCCUCUCAGGGAGCUGCUCCCUCUGCCAUGGUCAGUGAGAGGGGGAAGCAGGAGCCGCCAUUGGGGUUGUUGAGUUCGUGGCUGCAACCCAGGGAUGAGGAAGCUGCUGCUACACACCCAUGAAGCUGAUGCCUGGACAUAAAUCCCUACUGAUAAGUGUUUACGACAUUUCCAGCGUGGUGCCGACACUGCAUGGAAAUGCUGCAUGGAAAGUCCUUAUACAUCUAUCUUUGUGCAUUUAUUGUGAGCACCUACUAUGAGUAAAACCUGGGCUGGUGGCUGGAGAAACAUGAAGAUGAGUAAGAGCCAAUUCCUGUUCUUGGGGAUUUAAUAAUAUAUUCAAGGGAAAAGACACAAAAUAACCAUUUCCAGGAUUCAAGUAUUUUGUUUCGUGCGCAUUUCCAACCCAUCAAAUCAGCUGCAGGCACCGCACCGUCUAACAGACCCAGGUGUUCCUGCUGGAAGAAACUGUCUUUAAGUUUCCCAGAAUUGAAGGGGCUUUUCUCGCUUGCUCACGCCCACUCUUUUGAAACCCUAAUGGCUGAAGAGCAUCAUCAAGAGAAGGGGAAGAUGAAGCUGACUCCCUGCACCUGCUUCCUCCCCAUUCUGUUGGCUCGGGUCGGUGUGGGCUUUUAGCCUCUCUGAAUGUGGAGGUUCCCAGGGAUACGGGGAACCACAAAGGUCCAUAUUCUCAAAUGCAGCACUUCUUAACCAAGGCAUGGCUUUUUCUAGGUGGUCGGAGGCCAAAUACUCUGCUGCUGGCCAUCCCAACCAGUAGGCACAGGGAAAUGCCAGAAAAGAAGCAGCUGGGGCUUCUCUUGCUGAGGAAGAGGGUGAAAUGAACCUUGCUUGCCGCAGCCAGUUUCUGACCCUGCUGCAGAGAUGACGGAUGAGAUUCCAGCUGUGAUGGAGAUGUGGUCCUGGGAGGCCAUUCUAGGCACUGCUCUUCAAAGAGGUUGUCUCCAUCCUGGGAUAGAAGUUCAUAAGGGGAAAUGUACAAACACAGUUUUCCUGCCACCUCCAAGCUGCUUGGGGCCGGACUGGAUGCCCUGCCGGCCCCUCACUCUUCUUACCUUUGAACAUCGACCCUGGCCAGGCAUUUGUUUAGGCAGGUUUUCUAAUUUAACUUUUACAACAACCUGUGAAAUGGCUACGAUUAACCCGCUUUCAUGGCUGAGCACCUGGCUGGGAGAUGUAAGGUACUUGCCCAAGGAAACCAAUCAAUUAUCAACCUGAAUUUGCCUGACUUCCCACUCAUGCUUUGGUUGCAGUUCCAGAGUCUGCUACAGGAUCUCCCAUACAGAGUGGCCUGAAGGCACUGGUUUCCCUUGGGAAACAGCGAACUCAUGUCCCUGGACUUCUCCCCUGUGGCCUCCCUCCCUGCUUCCCUGGGACUGUUAGUACCUUCUCCUAUGUUUCAUGUUGACCAUACAGCUUUGCCUUUUUCCAGUCUAGGUUUAUGCCAGACAUUGUGUCUGUUAUUUUCCCUUUUUAAAGUGAUAUCUGGGCUGAGUGCAAUGGCUCAUGCCUGUAAUCCCAGUACUUUGGGAGGCCAAGGCAGGCGGAUCACCUGAGGUCAGGAGUUCGAGACCAGCCUGACCAACAUGGAGAAAUCCCAUGUCUACUAAAAAGACAAAAUUAGCUGGGCAUGGUGGCAGAUGCCUGUAAUCCCAGCUAUUCAGGAGGCUGAGGCAGAAGAAUCGCUUGAACCUGCGAGGCAGAAAUUGUGGUGAGCAGAGAUCACGCCAUUGCACUCCAGCCUGGGCAACAAGAGUGAAACUCUGUCUCAAAAAUAAAUAAAUAAAUAAAAUAAGUGAUAUCUGUG

Taxonomic tree

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Publications