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Homo sapiens (human) mir-99a-let-7c cluster host gene (MIR99AHG) URS0000A770A7_9606

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MIR99AHG: MIR99AHG is a long non-coding RNA (lncRNA) that plays a role in various biological processes. It has been found to increase Let-7c expression, which in turn promotes autophagy by targeting mTOR and ANXA2, leading to the suppression of growth and motility in lung adenocarcinoma [PMC8745176]. Additionally, MIR99AHG stimulates the Notch signaling pathway by sponging miR-3129-5p and targeting NOTCH2 [PMC8675481]. In adipogenic differentiation, lnc13728 inhibits the WNT-β-catenin pathway through ZBED3 upregulation, while lncH19 enhances C8orf4 expression by sponging miR-30a [PMC8675481]. Conversely, lncFR332443 suppresses preadipocyte differentiation by increasing RUNX1 expression and inhibiting MAPK signaling pathways [PMC8675481]. MIR99AHG promotes adipocyte differentiation by binding to miR-29b-3p to regulate PPARγ [PMC8675481], while lncRNA U90926 inhibits adipocyte differentiation through PPARγ transactivation prevention [PMC8675481]. MIR99AHG has been identified as a potential tumor biomarker for prognostic assessment and targeted therapy [PMC9037265], and it is also involved in LUAD fibrosis progression inhibition through the absorption of miR-136-5p [PMC9502606]. Furthermore, MIR99AHG overexpression promotes apoptosis of H1299 cells [PMC8087685], and it is a polycistronic miRNA host gene encoding three intronic miRNAs: miR-99a, let-7c, and miR125b2. In co-expression networks, A930037H05Rik and MIR99AHG have the highest number of interactions in M1 and M2 activation, respectively [PMC10085744].

Genome locations

Gene Ontology annotations

Sequence

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AUAAAGGACUUGUCUAGGGGAGAGCCUAUGGAUCUGAGAACGCUGUCUGGGCUUGGUACCAAGAGCUGGUAUUUCACAGCAGCGACCGCCUCACAGACGAGCUGUGGGAAGCAGGAGGGAGACUCUCUCUUAGGGUGCCACUACUAUGGAGACACAGCUGGGCUGAACAAGAUUUGCUUCAAACGACAACAAGAGAGACAGAAAGUAUCUGGUUCAACCGCUGCCCGAGCAGGCAGGCACCAGAAGAGCUAGCAGCCAAUCCGGCCAUGCUCGAAGCCAGCUCUGCAGCUCAGCCAAUCAGUGACAUCAUUGCUUUCUUUAGCUUGCCCAUGGUGAUGUGAAGAUGAGAAGAAAUAGCAAGGCCCAACCAGUUCUUCAUCUGGAGACAGUUCAACGUUCUGCAAACCAGAUCUUCAGGAAUUUUACUGGGAUAAUUAUCCAAAUAAAUUGCAAGCAUUCUAUCCAAAUGGACAUCCAUAAAAAUUCAUCAGAGAGCAUUUUACUACUGAGCUGCAAAGGGAAAAACUUAAAAUGGAUAUGAAAAGUGAAGAAAGUGAUCAUAGGAGAAAACCAUUUCAGGUGUCUGAUGAUUUGUGAGCCUCAAGUGACUACUCUGUGGAAUCAUCUGUCCUUGCCUUUGAAUUAGCUUUCCCUAGGCCAUGAGUCAACAUUAGUAGUUUAUACAUCCAAAUUGAUGACAAGAGCACCUCAAAGGCAGCAGCCUCAAGGAGCAGCCAUGGCCCCAGACUUGUCGCACGGAUGCAGAAAACUUAAUGGAGGAGGCUGAGGUCAGAAUGGGAAGAGUUUUUAAAAAAUAAAAAGGGGAGCUAAUAUGUGAGGAACUGAUUGCUGUGCAUUAUUUUCCACUGAACAGACCUUCUUUUAACUUCUAAUCUCAAGCACAUAGCAGCUGUUGUUUUCAUAUUAAAGAUCAGUAAGUGUUUGUUGAAUGAAUGUAUAAAUUCUUCCCCAAUCUCUGUUCCAUGUAAUAAGAACUAAGUUAGCAUUCAAUUAUAAAGAGGACUUAGAAAGUCUGCAGACAUUUUUGAUCAAAAAUCCUUUUAACUGUCUUCUUAUGGUUCCCGGUAACACCUAAGCCCAAAAAACUCAGGUCAUUUCUUGCCUGUACUGUUGCAAUAGCCUCAUAAUAACUAGUCUUCUCCUUUAUCAACCACAGUCGUCUCCGCUACACAAAGAAGAGAGGGUGCUAAUCUAAAGUGUAAAUUAUUUUAAAUCAGCACCCUUCUUGUAAUUUCCCAGUGGUUUUUCCUGUCAUAAGAAUAACAUGCAAAAUUCCUUGCUUGCAAAGCCAGGUAUGACCUUGCCCCGUCUACCUUACUGGCAUCGUCUCUCAUGACUCUUCCCCUUUUUCACUCUCCAUCUUGCCUUUUCCCAACCAUGCCUGCUAGUGAGCCUUAGCCCUUGUGUUUUCUCUGCCAGGGAUGCAUGACUGGCUUCUUUACUUUAUUCUGAUCUCUCUGCUCAAAUGUCAUCUUUUUAGAGAUAGCUUUCCUAAACAUCUUUAAAAGUACCCCAUGAACUGUGAAACACCUUUCCUGCUUUUUCUUCAUAGUACUUAUCACUUCCUGAUAUUAUGUUAGACAACAAGCAAAUAAGUAUAUGCUGUUCCCACUAAAAUAUAAGCUCCAUUUGAACAGGAGCCUUGAUUAUUCCUGAGUAUACCCCUAGUGCCCAGAACCUAGUAGGGCUUUAAUAAAUAUUAGAUUCAUUUGUUGAAUGAAAAAAUGAAUGAAUAAUUGAAUAAAGAUAUCCAGGUAGAGUGUCCGGGCAGCCCAACCUAUGUGAAGCCAGUACAAGAAUGUUUCUGUGACAUAGUGAGCGCAAUUAUUCCUCUAAAUGAUGAACUUGCAUGAGUACACAAGGAUAAAAUUAAGCACGUAGUUUAGAUUUCUGCAAGUCUCUUCCUCAGAUUGAGGAAAAACAAAGAAAUUGAGCUUAUUCUCACCUCAUUCUUACAUGAACUAAAUCCAGAAUAAAGCAUCAUUUAAAUACCAAGCACAUCCCUACCUCAGCCACUCAUGGAAUACUUUAUCUGUAAAGGGACAGAUAGAUAGUAAAUAUUUUUGGCUUUGGGGACCGUACAGUCUGUGUCGCCACUACUCAGCACUUCUGUUGAGGUGUGGAAUCAGCCCUAGACAACACAUAAACAAAUGGGUGUGGCUGUGUUCCAAUAAAAUGUUAUUUAUAAAACUAGGAAAUCAGCAGAUUUAGUCCACAGGCUGUAGUUUGCUGACCCUUGAAUUAGAGAGUCUUCCCCAAAUCCUCUUCCCAAGUUAUUGAAAGAAUGCCCAUAGGACCAUAGCUCCCUCACCUGGUUCUUUCAAGAAAUGAGACAAAUUCAGGGAUGGUUGGAGGGUGGAACGCCUACCUGUGACAUGACUAUUGAGCCUGAUUUCUUUCCUUUUAUCUCUUUAAAGUGAGUCAGGUCUUAACUUUAAACUGUCUCUAAAGUGGCAAUAACUGGGCCAUGUCAAAUACUCCCAAUGACAAAAUUUCUUCUUGGAGAAUGAAUGAGGGUUGCAUACAGUGGUGUGUUGGUAAAUGUUUAGCAACUGGCUCUCUUACUGAUUUCUGUAGUGUAAAUUCUCCCAUCCUGGCCAUCUGAAACUACCAAUAUGAUGUCACUUGAUGUAGAGUUGGGAAAAGACAGUCUCUUGAAUAAGUAUGAGCUGGUUCCAGCCCACUGCUGAACACAUAUUUAAAAGCUACAAUAGCUCUGCUCACUGCCAUUGCAGAGUCUGGAGGAAAGAGUAGCAGGCUUGAUAGGAGCAAUUGGCUGAAUAAUCUUUUGCAAUGCCAAUAAAUAAUGAAAAAGUAUAUAAAUAUAACGCUGUAUAGAAAGCUCUCAAGUUCAGUGUUUGGUUAAAAUACAUACUCAGUAAAUGGUAGCUAUUAUUGUCUUAGUUUAAGUUAUUGCAAGCAUUAAAAUUAAAUGUUUAGCUACAGACUCAAUCCAGUUUUAAUGUCAUUGUGUUAAUAAGGCCUCUUAACAUUGAAGCAACAAAGAUAAAGGAAUUUUUUUGUAGCUAUUCACGAUUCUGCCCAGCUCAAGGUAAAGAUAGCAACAAAAUACUCCAACCAGAAUAAAAGAAGUCUCCACUUGACUGCAGCUCUUCGCAACACUUCACAAGGGUCAAGCUGUGUUAGUUUCCUUCAGUGUUAAACAGAAUGCAUCUUAAGAGAAUAGUUCAAUUAUUGAUUGAAUAGUAGGUUCAAGUUGACUAUAAUCCCAACUAAUACACUCUAAGACCAGGGAUGGGCCGACAGAAGGGUAAAGUUUUCCACUCAAGUCUCGAGGCAAACACUCAGAUAGAAGUAGUAAUAUGGAUGCCUUCUAUUAUUUGGUCACAUACAAUACUGUUCCAGCCCAGUUGUGCAAAACUGGUGAAAUAAAAGGCAAAAAUAUUGACAACAGUUUGGGUAACUGGAUUCCAAAAUGGGCAUCCAUCUAAGAGAAAUUAAUGAAAAAAAAGCAUAUGGACCUUGAAAUACAUUAAUACACAGUUUAGGUUUAAACACUCAGUUUUUAUUAGAAAAGACUAACUUAUCCUGUUUUGAACACUACAAAAGUGCUUUCUGAACCAUUUACUCUCAAACCUCCUCCACCCAUUCCCCUCCAUCUAUAACGCUUUCUGCACAUCUGUAAAAGGUAUGACUUAGUGUUUGGUCUGUGAAAUAAGGUUAAAAAGGAAGCAUUUCUUUUUACAUUCUAGCUAAUGUUGAUAUUUUUCUCAUGCUUCUAUUAGCACAUAAUUCAGAUACAUUAGUUUUGAAGUUUUGAAUCUUCUCUGCUUCUUGAGGGCUCUCUGUUCUAGAUCAACAUGAUCUGUGGAACACCAGCCAAGUCCUGGGCAGAACCCUCCCCGUUGUCCAAAUAUUACUGAAUCAGUUGAGUUUUCUCUGUUGUCAAUGAAUUAUUCCACAUGUUUCUUUGGCUACAUUUUUUUUGGCUUUCUGUUCACAGUAAAUAUAGCCUUUGUUUUUAAAAACUUCUAUUAUGAAAAUUCCAAAUAUAUGCAAAUUAGAGAGAAUAGCAUAAUGAACCUCUAUGUGCUUAUCACACAUAUAGGUUCAACUAAUUAAAUUAUAUCAAUUUAUGGCCAAUCUGGUUUCAUUUAUAACAUCAUUCGCUCAUUCCUAACUCCCUGGAUUAUUUGAUUGACAUGUUUCUAAAGUUCCUUUUAAUCUGUAGGUUCCCCCUCUCAUUUAAUCUUUUGCAACUUAUUCAUUGAUGAAACUGGGUUAUUUGUCCUUUAUUGUUUCUCUCAUUCUGAAAUAUGCUGUAAUGUCAUUAACCAUAUUCUUCUUUCCUGUAUUUUCUGUAAGCUUUGAGCUAGGCAGAAAUAUUUUAAUCAGAUUCCUUUUUUUUUCUUUUAGCAAGAUUUCUUCAUAAAUAAUAUUGUAUGUGUUCAUGAAAAUAGAAAUAAAAAUAGAAAUAAAGAAGAAAUAACAGAAAA

Taxonomic tree

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Publications