v24

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Homo sapiens (human) ZNF433 and ZNF878 antisense RNA 1 (ZNF433-AS1) URS0000A76F75_9606

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ZNF433-AS1: ZNF433-AS1 is a long non-coding RNA (lncRNA) that has been studied in various contexts. Stable expression of dCas9 and sgRNAs targeting the transcription start site (TSS) of ZNF433-AS1 has been shown to inhibit the expression of the gene, leading to a decrease in cell proliferation [PMC7104257]. It has been suggested that the growth inhibitory effect of ZNF433-AS1 knockdown is not due to perturbation of the overlapping coding gene, ZNF433 [PMC7104257]. ZNF433-AS1 is localized in the cytoplasm, making it a suitable target for RNA interference-mediated knockdown [PMC7104257]. ZNF433-AS1 and TTN-AS1 are oriented in a tail-to-tail manner relative to their corresponding sense genes, partially overlapping with their coding regions [PMC7104257]. In studies related to proliferative vitreoretinopathy (PVR), it was found that ZNF433-AS1 was expressed at lower levels in PVR patients compared to patients with idiopathic epiretinal membrane (iERM) [PMC7842006]. Additionally, ZNF433-AS1 has been shown to suppress its sense gene, ZNF433, which plays a role in multiple sclerosis [PMC7842006]. In another study on endometrial cancer (EnCa), overexpression of ZNF433-AS1 was observed in EnCa tissues compared to normal tissues [PMC7893582]. Knockdown of ZNF433-AS1 has been shown to inhibit cell growth and proliferation in cancer cells [PMC7763270][PMC8200053]. Furthermore, epigenetic changes near the gene cluster containing ZNF763 and ZNF433-AS1 have been associated with disease outcomes [PMC9780337].

Genome locations

Gene Ontology annotations

Sequence

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AAUCCGCCGGAAGGAGGGCGCAGCAUUGCCGGUCUUCUCAUUGCCUGGCUGCUAGAGGAAACCCGAAGUCGGGAUUCUUUCUUUCCUGCUCUGAGAGGGACCAGGUCCCUCCUCCGUAGCUUUUGUCUCUCUAUUGCCUGCGCCGUGUCCUGGACUGCUCACGGGAGUUCUGCAGGAGACGCCGGAAUAUCUGGAAGCUGAAAAAUGGAAAUAAAUGGAAAGACCAGAAUAUUGAAGAUCACUACAGAAAUCUAAGGAUGAAAUCAACAGCCAAUCUGGGUGCCAUUGAGACAUCUAAAGCCUUACUAUGAGCCAGAUACCCAGGAAGAGGUUUUGGGAGGAUCCCAAAGACUCCCUGGUUGCAGCCAUGUCAAGACUGAUGCUGAGGAGGACCCCAACUGUCACGAGCAACAACUGCCUGGGGACAGAUCAAGAAGCUGUCACAGAUGGCAGAGAAAAACCUGAGAAAAGCGGGACAACCAGUCACAAUGAGUAAUUUAAUGAUAGCUAUGACAGUGGUGAUCACCAUUGCCAUGAGUAUUCCUUCAACAAGGGCUGACACAGAGAACAAUUACACUUAUUGGGCAUAUUUAUCAAUCUUGGCUGGCAAUAAUGCCUGGAUGUGAUCACUCUAUGACACAGUUACACAUGCUUUCUGGUCUCAGUAUUUACCAUAAUAAUCUGCUCCUAUAAUUGAGGCAUACUGCCCUCAAAAAACUAUUUGUAAACAGGAUUGGACCUGGUCAGAAAAAAUGAACGUACUUGUUUGGGAAGAUUGCAUUGCAGAACAGGCAGAGGUGCUGCACAACGAUUCCUAUGGAGUCAUUAUUGAUUGUUCCCCUAAGGGGAUGUUUAGCUUGAAUUGCACCUCUCAGUCUGCCUGCCAUGGCCACACUAUGUUCAGCUGGUCUGAACAAAAUGGUCAGAUGGUAGAAAUGAUAAGAAGUAUGGCAAGAGUUCCUAUUAUCUGGAAACAUGGUGGUAUAGUGGCACCUCAACCUCAAAUGAUAUGGCCUGCUGUAGGAGCUAAACAUAAGGAUUUGUGGAAACUAUUAAUGGCUCUUAAUAAGAUCAAAAUUUGGGAAAGGAUAAAAAAGCAUCUAGAAGGACACUCUAGAAACUUGGAUAUUGCAAAAUUAAAAGAACAAAUAUUUAAAGCAUCCCAGGCACACCUGACCUUAAUGCCAGGAACUGGAGUGCUUGAAGGAGCUGCAGAUGGAUUAGCAGCUAUUAACCCAUUAAAAUAGAUAAAAACACAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications