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Homo sapiens (human) IL6 antisense RNA 1 (IL6-AS1) URS00008E39B4_9606

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IL6-AS1: High levels of IL-6 and lncRNA IL6-AS1 were reported in COPD subjects with concurrent upregulation of miR-149-5p and early B-cell factor 1 [PMC9237255]. The cytoplasmic form of IL6-AS1 acts as an endogenous sponge for miR-149-5p and stabilizes IL-6 mRNA [PMC9146199]. In the nucleus, IL6-AS1 recruits early B-cell factor 1 to the IL-6 promoter, leading to increased methylation of H3K4 and acetylation of H3K27, which promotes IL-6 transcription [PMC9146199]. The IL6 promoter region contains six single nucleotide polymorphisms (SNPs) that overlap with the intron of IL6-AS1 [PMC10148000]. One specific SNP variant, rs2069857 c.-48, is found in the intron of the overlap sequence between IL6 and IL6-AS1 [PMC10148000]. IL6-AS1 acts as an upregulator for IL-6 by sponging miR149-p5 to stabilize its mRNA and recruiting epigenetic modifiers to increase active H3K4me3 and H3K27ac at the promoter region [PMC942484].

Genome locations

Gene Ontology annotations

Sequence

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CUGAGAUGCCGUCGAGGAUGUACCGAAUUUGUUUGUCAAUUCGUUCUGAAGAGCCCCCCAAGCCUGGGAUUAUGAAGAAGGUAAUACUACCAGUCAUCUGAGUUCUUCUGUGUUCUGGCUCUCCCUGUGAGCGGCUGUUGUAGAACUGCCUGGCCAUCCUCAAAUUUCGUGCAGUUACUUCAAGGCGUCUCCAGGUGGAGUGUGUGACUCCUUUUUGCCACCGCGUGGCUUCUGCCACUUUCUUCACCUGCUUCAGCCCACUUAGAGGAGGUUGGCUGCUGCCCUGCCCUCUCCCAAGUGACCCCUUGGGAAUCCUCCCAGUGAGGACUUUGCUCUCUGUGCCAGAGGUUUGCCUUGUGCUGCCAGUGCUCUCCCCAUUGCCACUGAGUCUCUUCACCACUGUUUCACUGGGGCACCUGCAUGGGCCCCAGGUCUCCUGGAGCCCUGAAAUUACUGAAGCCCACUUGGUUCAGGGCAGAAAGGGGGAGAAUACUACUCACCUCUUUGUUGGGGAUGUCAAAGGAGGACCUUGUGGCAUCUUGCAGAGUUUGUGUUUAUCGCUCCCUCUCCCUGUAAGUCUUGAUUUGAAAUCAAAAGAAGCUAGAAGGAAACUACGGACGCAGGCACGGCUCUAGGCUCUGAAUCUGCUUCCGCGUCGGCACCCAAGAAUUUCUUAUUGGGUCAAGCUGGUUCAGAAGCCCUCUUCCCUCAGGAUGGUGUCUCUUGCAGGAGGAUCCUUGGUCUCAUGCAAAUGGGCUCUAGACUAGGUUGUCCCUCCAGUCUCCAGAGACCCAGACAGCUCUGAGAUGGCUUCAGGCUGAAACCAGACCCUUGCACAACACCAAAACACUUAUUUACCAAACAUGGUGUUACCUUCACAAUCGGUUUCUUUGCUUUGCUAAGAAGAGAUCUCUUCAAGAUCGAUAAAACAGUGACCUCUGUUGGGCAUUUACUCAAGUUUUGUUUCGUGCAUAACAUUUCAGGACCCGCCUGUUGGGGAAAGUGAGGUCAUCCAUUCUUCACCGAUUGUCUAAACAGAGACGGUGGUCCUCUGCCGCGGUGGGAUUCUUUGGUGUGAAAAUGAAAAUGGGGGAGGAUGGCUGGAUGGUUUCAUUUUUAGUGCUCUCCUGUCUUAAGCAACGUAGACACUCCUGAACCAAGUUCUCUUUCCUGCAUGAAACGAAGCCACUGCUCCCAGCUCCGCAGCCGUGCACUGUGAUCCGUCUAUGUAAUGUGAGCUUGCUUUUACUCAACUAUCUAUUUUUUAGAAAAUACAAUUCAAUAAAUUUCAAGUACUUGAACUGAGUGACACAAUACAACACACAGAUUUAUCUUUUCAAUAAAAAGUGUUUUUUAAAUAGGAAAAAAAAAAAA

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Publications