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Homo sapiens (human) long intergenic non-protein coding RNA 312 (LINC00312) URS00008B8B78_9606

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LINC00312: LINC00312 is a long intergenic non-protein-coding RNA (lncRNA) that has been studied in various cancer types. It has been found to inhibit colorectal cancer cells by binding to miR-21 and increasing PTEN expression [PMC7215884]. In a study on smoking-associated lung cancer, LINC00312 was identified as a key lncRNA, but its accuracy was found to be lower than in another study [PMC9070410]. In the diagnosis of primary biliary cholangitis (PBC), LINC00312 showed an area under the curve (AUC) value of 0.7292 [PMC8108032]. LINC00312 is located on the 3p.25.3 loci on a chromosome, which is commonly associated with allelic loss, particularly in nasopharyngeal carcinoma (NPC) [PMC8231241]. At the molecular level, LINC00312 directly binds to the catalytic subunit of DNA-dependent protein kinase and inhibits its interaction with the Ku80 subunit after DNA double-strand breaks [PMC9008121]. It has also been found to be downregulated in non-small cell lung cancer tissues and suppresses tumor proliferation by regulating HOXA5 expression [PMC7318166]. Additionally, LINC00312 expression is positively correlated with fibrotic factors such as α-SMA, COL1A1, and fibronectin [PMC8578048]. In NPC cells overexpressing LINC00312 under irradiation conditions, deregulation of the PI3K/AKT pathway was observed [PMC7801696]. Interestingly, LINC00312 is negatively correlated with tumor size but positively correlated with lymph node metastasis [PMC7843584].

Genome locations

Gene Ontology annotations

Sequence

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UUUUCUUUUGAUAGAAUGUCAAACUUACGAAAAAAGUUACAAGAAGAGAACAAAGAGCUAUUAGAGGGUGUUGCUGACACAAUGCUUUAUCACUCUUGAAUAUUUUCGUGUGUAAUUCCUACAAAUAAGGACAUUCUCCCACAUAGCCACAAUACAACCAUCAAAAUCAGGAAGUUAACGCUGAUGUGUUUCUACCAUGUAAUCCUCAGAUCCAAUUCAAGUGUCACCAGCUGUCCCAAUAAUGUCUUUUAUAACAAAAACAUUCAGUCUAAGAUCACUCAUUCUAUUUAGUUAUCUUGUCUAUUCUUCAAUUUGGAAGUGUUCUUUGUUCUUUCCUGAAUGUUCAUGACCUUGACAUCUUAGAAGAUUAAAGGUUAUUUAAAGUUGUUGAGUUAAAUAUCCAUUAAAUUAGGUUUGUCAGAUAUUUCCUCGAAAUUAGAUUCAGCUUAUGCAUUUUUUGGAAGGAAUACCACAGAAGUGAUGUUGUUUUCUUUCUGUUGCAUCCAAUCAGAUGAUACAGGAUUUUGAUUUGUUCCAUUACUGUUGACAUGAAUUUUGAACAUUUGAUAAUGCCAGUAUCAGCCAGAUUUUUCCAUUGUAAAGUCAUUCCUUUGUCCUUUGUAUUUAAUAAGUAUGUUUAGGGACUUUGAGACUAUGUCAAUGUCCUGUUCUUCAUCAAAAUUCCACUCACUCAUUCUUAGUAUUCAUUGACGUUUACUGAUCGAACUAAUUAUUAUUAUGAUAGUUGCCAAAUGUUGGUUUUUCUAAUUCAAUCAUUUCUUUAGUGUUUAUUAGCAUUCUACUAUAAGGAAAAGCACUAUCUUCUCCCCAUUUAUUAAUUCACAUAUUUACAUCAGCUUGGAGUUAUUGAUUUCUAUUUUAUUAAAUAGUUUAUAAUUGAUUACCAUCCUUAUUUAUUUUAAUGCUCAAAUUGUCCCAAAUUAUGGCCAAAGAAAGCUCCUUCAAACUGGUUGCUAUGUCCUUUUGACAUGGCCCAUCAUUCUUUAAACACAUUUUACAUCUGGCACAAUAACGUGCUACAUACCCAUCUUGUAUUUUUCCUGCCCCAUCUUUGAAAUCAGCCAUUCUCAAGGGGUUCCUUCUUAAUCUGGCUGUUGUUGUGUUGGAACUCCUGGUACCAUCUUAGAACCUUAAGGAGACAAGCGAACCAAGCCAAUAAGCUUUCCAUGAUGCUGCUUAGAGUUAAACAGAGCCCAGGUACUAAGUUAUGUCAUGGAGACAGUGAACUAACCUCUGGACUGCUUGCUACAUGAGACAAUUGAUUUUCUUAUUUUCUAUGUAGGGUGGUACAUUUCCUCAUUUUGAGAUAUUUCUUCAACAUAUAGCUUUUCAUUAGUGGGGAUUUUGUCAAUUAUAACCAAAAACAAUGUGACGGAUACCCAAGAUGUUUCAUGUUGUAGCUUGGGUGAAUUACACAUUUCUGAAGCCAUUACACUUCCUAGUUUAUUUGGAUUUAAGUUGACAAAUAAAAAUUGCAUAUGUUUAUGGUCUAUAACAUGGUGUUUCGAUAUAUGUAUACAUCGUGGAAUGGCUAAAUCAAGCUAACAUAUCCAUUACCUCACAUAGUUAUUUUUUGUGGUGAGAACAUUUUAAAAAUAUUGUCUUAGCAAUUUUCAAUCAAGCCUGUCCCAUGGAGACACAAGCAAUAGUGACAUGAGCACUUGACUCGCUGGGUUAUCAGGCUUUGGCUCCAAAUGUUUGGCUUCAAAUAUGAAAAAGUUACAUGAAAGAUGAAACUAUGCAAUGGCAUGGCUGUUGGUCAUUCACAUCUCUCUCUGCCAAGAAUGGGGAUGACGCUGUUGAAGGAAGAAAUGUGUUUUCUCCUUUUUCUCAAGUGAUAUUUGCCUUAGGUCAGAUUCUACUAGUUUAAAGCAAAACGAUCUCCUGGUCUGAUUCCUUUGGGUCUCUAAUAAUGGAAACUGCAAGGAUCAGCAUAAAGUGUUCCUUUGUUCUGACGUUGGUAUAACAUUGCUUCUUGAAAAAUGAAAGUAUUUGGACAUACAGACAGAAGCAAUAUUAUUCAGGUCUUCCUUGUUGCAAGUGAGGGAAAUCCAAUUAAAACUGGUUUAAACCUAAAAAAAAAAAAAAGAAGAAAAGAAAAGAAAAAAUAUGAGAGGGGUUUUGCUUUCUGGAAUCUGCUUUCUAGUCAGAAAGUGCAGAAGAAGGGCUAGCUUCAGGAACAAUUGGAUGCAGUAGUUCAAAUCACAAGUUAAGUCUCUGCUUCUUUUCUCCAUCUCUCUUCUGUCUUCCUCCACACUGGCUUUAUUCUUAGGUAGGCUUACCCAGAUAGUCAUAAACACAGCCACCAGUGGCAGCUGGGCUCACUUUUGUCCUUGGAGCCAGUGAGCCCAUGAAAAAGGAGCUUCUCUUUCUGGAGCUUCCCAGGGGUAACUUUGAUCAGCCAACAAGGGUCAGUCCUAUGCUUAUCCCUUGACCAAUCUCUGUGCCCAGAGGGCAGGGUACUCUGAUUGGCAAUACCUUCAUCGUGGGCCAACCACUGUGGGGAAGGGGGAGGGAUUAGAAAAGACAGCCACACCCAAAUCUCAUGAAGCAGUCCCCUUUAUUUUAAAAAAGUCCCUGUGAGAGCAACAGGAGCAAAGCAUGGAGAAGAAGCAAUCUUGGAGAAGCUGGAAGAGAACUGACCCAAAGAAUCCAAGAGACUAAGACUGUGCAGGGUUGGGGAACGGAAGCUCACACAGGAGGCCUGGACAGAGCUGCAGCAGAGCCAGGAGAGAAGCCAAGUGGCACAGCUCAUCUUGAAGUAAUUAUAAUGCCACUAAAAUUCUCAUUUGUAUUAAUUUUUUUUAAUUACUGGCAAGAUAAGGCAAAUGUUUUUAAAGGCCUAAAUAAAAUGAUAUUCCCUGAA

Taxonomic tree

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Publications