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Homo sapiens (human) long intergenic non-protein coding RNA 434 (LINC00434) URS000081220A_9606

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LINC00434: LINC00434 is a long non-coding RNA that appears to target several genes involved in cancer and autoimmunity, as shown in Supplementary Table S4 [PMC9619055]. One of the genes that LINC00434 is close to is Diaphanous homolog 1 (DIAPH3), which modulates mTOR signaling and cellular proliferation, and Tudor domain-containing protein 3 (TDRD3), a chromatin modulator also involved in proliferation [PMC9619055]. It is suggested that LINC00434 may be imprinted, but this hypothesis needs to be tested in other tissues to confirm [PMC6589892]. There is an imprinted transcript that is antisense to LINC00434, and the two genes share a bidirectional promoter [PMC6589892]. Although no expression of LINC00434 was detected in lymphoblastoid cell lines (LCLs), it is hypothesized that it may also be imprinted since it shares a promoter with the imprinted transcript [PMC6589892]. Interestingly, a previous study on DNA methylation in oocytes found maternal-specific methylation on the bidirectional promoter of LINC00434 [PMC6589892]. It is proposed that this represents a maternally imprinted transcript transcribed from the forward strand and sharing a bidirectional promoter with LINC00434 [PMC6589892].

Genome locations

Gene Ontology annotations

Sequence

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CGCUUUUUCUCUCUAUCAGUCCUUGUGUCUAUCACUCGCUGCGGUCAGCUGCCACACCAAUUCUUUGGUGUGGCUAGGCAAGAACCUUACGUGUUACAUUUUGGCGAGCCAGCCAGGAGUCUCCAGGAAAGGCAUCUAGAUCGUCACAUGCUUCUUCCCUCCAGGUAAAUUGCAGACGUGAUGCUCAGAAUUAAACUGUCAGGAUGCUGCCAUUCUGCUGCAUGCUCCGGACAGCUGGCCGUUAGGGAGCACUGCAGGCUUGGAAGAGGUGACUUGUCUCCCUGUGUACAGCCCUCUGGGUAGAGCAGCUGUCAUCUAAAUACAGAUGCUGAUCUCCAAAAGAAGUUCCAGUUUGGUUACAGAGAGUUACAGCAUAGUGAAACUUCAAGAACUAGGUUUUUCUGGACCAUCCCAGUGCGCAUGAAUCAGGUGAUUUUAUCUUUUGUUCCUCUCCUUGCUAUCCCUAAUCUGUCAGGCAGUCCUAAAUCUAUACCAUCAGGCUUGUUUGUUCUACUUCUCUAUCCUUUUAUUAUGGUUCCAUUAACUCACAUCCAAGGAUGUCAAGAGAAUAAAUAGCCCAAUAAAACAAAAGAAUAUACUUCCAGAUUUAAAAAGAAAGAAACAUACAAGAAAUACAUAAAUCAUACUAUAUGACGAUAGCCCAGAAGAUUGCAUGGAGGAUCUUUGUGUUUCCUGUAGAAGAAAAGAAAAAUGGAAUUUCCAUCUCUUGCAUCAGCACUUGACAGCUGGAGUUAUUGUUGACCAGGCAUCAAGAAAGGAGGGAUAUGCAUCAGAAAUCAUUUUGCCUGAAAUAAGCACAACUCCAUGGAGGACAAUGACACAUUUUCUCUGGUGAUCUUGUAAUUGGGGAUGAUGUAAACAUGAGUCUAAUCUGCAUUUUGUCUAAGAAAUUCUUCAUCAUGAGCAUCUUCCAAUAAAACGUGGUUCCUUACAACAUGAAAAAAAAAAAAA

Taxonomic tree

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Publications