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Homo sapiens (human) lung cancer associated lncRNA 1 (LCAL1) URS00008121A7_9606

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LCAL1: LCAL1 is a long non-coding RNA (lncRNA) that has been identified as a candidate prognostic marker for lung adenocarcinoma (LUAD) [PMC9939659]. It is one of the seven key genes identified through variable selection and WGCNA analysis [PMC9939659]. LCAL1 has been found to be highly expressed in lung carcinomas and contributes to tumor cell proliferation [PMC7904782]. It is located on chromosome 6q14.1 and produces a three-exon transcript [PMC4156652]. LCAL1 lacks strong base pair conservation, suggesting a more recent evolution [PMC4156652]. Functional studies have shown that LCAL1 promotes cellular proliferation in lung cancer cell lines [PMC4156652]. It has been found to be overexpressed in lung cancer tissues, suppressing autophagic cell death and supporting cancer cell survival and proliferation through the deactivation of the AMPK/ULK1 signaling pathway [PMC8980082] [PMC9482549]. LCAL1 has also been implicated as an onco-lncRNA, with its overexpression promoting cellular growth independently of other common cancer mutations, highlighting its importance in lung cancer biology [PMC4156652] [PMC4615893]. Further research is needed to explore additional LCALs in lung tumorigenesis and assess their prognostic and predictive potential [PMC4156652].

Genome locations

Gene Ontology annotations

Sequence

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ACUAUUGUCUGUAAAAGGUACAACUACCUUGCUGAUGCUGUACAUAUGGCUCACUUGUGCCCAGAGAGAGAAUAAAGCCAUGUCGAAACUAUCUACGAUUCCUUGAGUGUUUUUCCAGCUACCUGCCACUUGCCCACCCACUCCCCUCAGAUCUCAGUUAGAACAUGACAAUUGGGCUCAUGAACAGGAUCCUGAGUGGUUGCAGGUGAACAAGCAGUUGGCACAAGGGCAAAGUGAUCACAUCCUGAUUGAGUGGCUAUGGACAGCCAUACAGACUGUGUGGAACAACGCUGGUGAAAUACCCAAACCAUUUAGAAGCAGUAAUGCCUCUCUUGCCUGGGACUGGGAUGGUGUGGCUGAGACUGCCUUACUGGCAGCCAGGUGCGCUAUUCAGCAGCCACAAGCCCUACAAGUAAUUAACCAGGGGCACCUGUUUGAGCUGGAGGUGCAUGUGGCCACAGACGGUUUUGGUUGAGGCUUGUGGCAAUGCACAGAGCGCCUAAGAAUGCCAGUAGGCUUUUGGUCCCAACUAUGGAAAGGAGCUGAACUCCGGUAUUCAUUGAUAGAGAAACAGCUAGCAGCUGUAUAUGCUGGCCUUCGGGCUCAUGAGAGCAUGACAGGACAGGCUGCAGUCAUCAUAUGGACAACUUACCCAAUAACAGGAUGGAUGCGUCUAUGUGUAAUGACCACCUGGAGUGGGAUAGCACAGAUGUCCACUUUGGCAAAAUGGGGCAACUCCUUGCAGCAGUGGAGUAAGCUGAGUACAAGUCCCAUAGCAGCAGAGUUGCAAGAGGUCUUGGGACGUGUAGUCCUAAUGCAAGAUAAGGCCAUGCGGCCUGAGGCACCCCUAGAUCCUGAGUCUUCACCAUUUAAGGAAGGGCAUCCCAGGAUUCCUGAGGGGGCAUGGUACACAGUAGAUGAGGUGCUACUGCUGCCUGGACCACUGUUGCAGUCCAACCUAGUACUGACACCAUAUGGUUUGAAACUGGGUGCGGACAAAGUAGCCAAUGGGCUGAACUCAGAGCAGUGUGGAUGGUGAUCACCAAGGAGGUGACACCUGUGGUAAUCUGUACUGAUAGCUGGGCAGUCUACUGAGGCUUAACCUUGUGGUUAACUACUUGGAAAAUACAGAAUUGGCUAGUGAGCCACAGACCCAUUUGAGGCCAAGCCAUAUGGCAAGACCUUUGGGAAAUAGGUCAUCAAAAAGAGGUAACUAUUUAUCAUGUGUCAGGCCAUAUGCCUUUGGCCACCCCUAGUAAUGAUGAGGCAGAUGCCUUGGCUAAGGUCAGAUGGUCAGAGUCAGCACCAACACAAGAUGUGACCUUGUGGCUACACCGGAAACUGGGACAUGCAGGGGGUAAACUGAUGCAACAAUUCAAUAAGUGUUGGGGUCUGUCCCUUCCCAAGCAAGACAUUUGUGAGGCUUGUCAGAAAUGCCUGGCAUGUGUUCAGACAUAUCCUAAAAAGAGGCAGCUGCCCGGUGUUAUACAACAAGUAACAAUAGGGUGAGUGCCCUUGACCAGGUGGGAAGUAGACUACAUCGGGCCGCUGCCAAAGUCGCGAGGGUAUACGCAUGCACUAACGGCUGUAGACAUGGCCACAGGCCUGUUGUUCACCUACCCUUGCAGGGUGGCCAACCAACAGAACACCAUCCAGGCCCUGCAACACUUAUGUUCCCUGUAUGGUUGUCCUCUGGCCAUUGAGAGUGAUAGGGGAACACAUUUCACUGGACAACAGGUACAAUGAUGGGCACAGCAAAUGGACAUAAAGUGGGGAUUCCAUGUGCCAUACAGCCCACAAGCUGAGGUAUUAUUGAAUGAUAUAAUGGGAUCUUGAAGAAUGGAUUACGCUUGCAUGUCAAACCCCUGUCUUUGCGGAGCUGGAGUUCCAGGCUGGACCUGGUGCUCCAAACCUUAAAUGAAUGGCCACAGAAAGGUGGCCCGGCCCCAGUGGAGGCUUUGUUUCACUAGGCCACCACCCCCAUUCAAUUGGAGAUACAUACCAAGGAUGACCUCCUCCGAUCAGGUAUGGGGACAAAUGGUAACCUGUUGUUGCCUGCCCCAACAACCCUGAAGGCAGGGGAACAGAAAACCUGGCUGUGGCCAUGGACCCUCCAAGCUCUCCACUGCUGGUGGUUGGCCAUCAUAGCUCCCUGUGGGGAGGGCCUACAGUAUGACUUGCAUGUCACUUUUUGAGUGUUCAAUACAUGGCUUCCAAGGUUGACUGUUUGUAGAGGAACAGCCAGGGAAGGAGCCCUCCUCUGAGGGACAUAUGUACUAUCUGAUGGGCCUAUUAUGAGCUACGCUGUGACUUUGGCAUGGAUACAGGAUUCAAAGGAACCAUGGAGAUUUGAGAAGGUGUGGUACCAUCACCCAGGGCAAAAGCCCUUGGUGGCUGCAUUGUUAUCCAGGGAUGGAAAGUUAGCCUAUAUUUUGCCUGAGGGAUGUGAUUUACCUCUGUUAGUACCUGUGCCUGCUCUGUCAUUUCAACCGUAGGUUAACAUGCUCCAAUUGCAUUGUGGACUGACCCCACACCUAUGCUGAGGUGACCAAUGUUUCCAACUGUUGGACCUGCACUGCCUUUCCAGCAGCAGCUGCAGACAGCUUUCCCUGACACAUACAUCCCGUGUCUGCAGAGAACUGGACAUGCCUGGAGACUUGAGAUCCCAUGGCUGAUGCCUGGAACACAAUGUGGCAAGCUUUGGACAAAGGACACAGCAAGACCCAUGGCUGGACCGUAGCAUUCGUGAUGAGUGGGGCUGGCUAGUAGGGGAACAUGUAGUAGCCCAAGCCCAGGCAUUGCAGUGCACAGAGCAACAUUGGGGUAACAGGAUGGGUACCUGUCACGGCCUGUGCAAACAUAACAUGUGUCACCACACUGAAGGUAUGGUGGAACAAGUGGCCUCACCAAGGUCGGACCCCAAUGGACUUUUUGCCUCUUGGGAGCUUAUGGGUCUAUGAGGACACAGUAGCCUUUCCUAUCAGCAAACUGGAGUGGAUGUUGUAUCUGGGGGUGGCCUUAUGUACCUGCUACUGUUCUCCCCACAUUGCCCAGAUGCCUGUAUAACUGGGAGGCACUGUGCUCUCAGUUUUUGCGAAUGUGAUGAGCCCCCUGGUGUUUCUACCCUUUGGCAAUGACUAUCCCUGGAGCAGGUGUCAAAACUGUAGAAGCACAAUUUACUGCUCUUGCGGAGCACACCGCUCAGGCUCUGAAUUACACCUGAGUGUCCCUCCUCCUGUUAAUGAAUGAGGUUGAUCAGAUCAAAAAGUGGUGUUGCAAAACCAAGUGGCCUUAGACAUAACUGCUGCCCAAGGAGCCACCUGUGCCCUUUUAGGAACACAAUGUUGUACCUUAUCCCUGACAAUCAGCAGAACAUAACAGCAGCCCUGCAAAGGGGUCUUCCAGGAGAUUAAGGUGACUGAGAGCCUCACUGUCAACCCCCUGCAGAGAUGGUGAGCAUCCCUAGGUUCUGGCGUACAUUGGGCCCUAAUAGUCAUAAGUAUCAUAGCUGAGAUCCUAGUAGUGAGCUGUUGCUCUCUGUAUUGUUGUUGUGGGUUAUGGACUCAGGGCUCCGCCAUAUAGGCAUGUGUCCCUGCCUGGAGGACGCCCUCAGCCUAGGGGGUGUAGUGUAAGGGAAAUGGCUGUGCUUUAGUCAGGAGUAGGCUGAGGCAGCCUUCUGGUGCAGCAUGACUCAGUGGGUUUGGAGUGCAAGCACACAACCUUGCUCGUUAUGUAACCACACCACAUGAGGCACAUUAGGUAACAACUCACAUGAGCUCGUGUUUGGCUCAGAGCCACUAUUGUCUGUAAAAGGUAUACCUUGCUGAUGCUGCACAUAUGGCUCGCUUGUGCCCAGAGAGAGAGUAAAGCCAUGUUGAAACUGUC

Taxonomic tree

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Publications