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Homo sapiens (human) X active specific transcript (XACT) URS00008120E8_9606

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XACT: XACT is a noncoding RNA that is involved in the control of X chromosome activity during human early development [PMC8183483]. Deletion of the TFB site resulted in the loss of XACT RNA expression [PMC6906429]. Approximately 23% of female hPGCs have one XACT cloud [PMC7717582]. In a study on DNMT3A/B compound mutant cells, >95% of cells retained expression of XACT on the presumptive active X chromosome [PMC8452533]. A novel technique called engineering XACT mice has been proposed by Morton et al. [PMC9183766]. In a study using mutant, double mutant, and control sub-clones, it was found that a significantly large number of cells had lost expression of XIST and began to express XACT from the eroded X chromosome over an 18-day growth period [PMC8452533]. Additionally, it was found that XACT competes with XIST in controlling dosage compensation during human early development [PMC8183483]. The expression of the XACT lncRNA gene is from the active X chromosome and it competes with XIST for controlling the activity of the X chromosome during human early development [PMC9588035].

Genome locations

Gene Ontology annotations

Sequence

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UUUGUGGAUGAGUCAAUGAAGAAACUUGUCAAAGCACUUCAAUUAAAACACAGAAACUAUAGAAAAUCAUCUGGUAAACAUGCUGAUGAUGUCCUAAACCUGAUCACUUGUCUCAAAAUUUAGAAAGUUAAUGGCUGAAGAUUCAGCAGCCAUUCUGAACUGGAAAUUACAUGUUAAGGCUGUUAUAGAAGAAAUAAAGAAAUUAAAUCUCUAUGUCCCCAAGGUAUCUCUAUACCGGCCUGGAAUGCCUAUCUCCAAACCUCCUUUACAUGAGACAGAAACAGCUUCUAUCACCUUAAAAUCUGUUACUUUAGGUUUUUUUCAUUAUGAGCAGCUAAAAUGAAUCUUACUUGAUACAGUGUGAGUGUUCAUGGAUUAGGGCAUUGUUUGAUAAGAGGAGUAAGAAAAGAAUAUAAAUUGUAUUGGCCCUGAUAUGCCACAAACAAUGAGGGCUGAAGCCAAAUUAAUCAAAGAAUAAACUCAAAUACAAAGAACAAAAAAAAAAAAAA

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