v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) lncRNA regulator of Akt signaling associated with HCC and RCC URS0000811F6D_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

LNCARSR: LNCARSR is a long non-coding RNA (lncRNA) that is overexpressed in sunitinib-resistant renal tumors. It competes with miR-34 and miR-449, leading to the upregulation of AXL and c-MET expression, reactivation of receptor tyrosine kinases (RTKs), and mediation of drug resistance [PMC5861621]. In hepatocellular carcinoma (HCC) cells, knockdown of LNCARSR rescues the sensitivity to doxorubicin treatment [PMC7757045]. LNCARSR has been found to be transferred via exosomes, promoting sunitinib resistance in renal cell carcinoma by upregulating AXL and c-MET expression in recipient cells [PMC9913720]. It has also been implicated in promoting the transformation of macrophages to the M2 phenotype, enhancing cytokine expression, phagocytic ability, and angiogenesis in renal cell carcinoma [PMC9817817]. In HCC, LNCARSR is involved in doxorubicin resistance through the PTEN-PI3K/Akt pathway [PMC7050132]. Furthermore, LNCARSR negatively regulates PTEN expression through bioinformatics analysis and RNA pull-down experiments [PMC7757045]. High levels of LNCARSR are predictive of worse overall survival (OS) and disease-free survival (DFS) in colorectal cancer patients [PMC7540992]. In summary, LNCARSR plays a role in drug resistance and tumor progression by modulating various signaling pathways. It may serve as a potential therapeutic target or predictive biomarker for anti-angiogenesis therapy response or drug sensitivity.

mRNA interactions 5 total

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
UCACCCAGGUGCAAGCCCAGAGGCAGUCUAUACCCCAACUCAACUGGCUGGUCCUCAAUGCUGCCUGCUUCCGUGCCCAACUUAGAACUACACAUCUGCUGCCUCUUGGUAACAUGUCAUUAUAAGGCUUCUUCAUCAGCCCUAACCCUGCCAACCACUCCUGCCUCACUGAAUGUGCCAACGGAUUGCUCAGCUCCAACCAAGGAAAAGAAGAAGGAAGUUGGAUACUUUAUACCCUCUACAUUGUCCAUUAGCAACACAACCUAGAGCUAGGAUGGAGAAAGAAAAUGCCAAAAUGCUAAUGAAAAAUGUUCAGAUGUAUCACAUAUUAAGCAUACAUGAUCUCAAAUAUUUUGCCUGAUUUAUGCUAUGCAUGCUAUUUUCCAUGUUGUGUAGGCUCUGAUGCUAGUCUACAUUUACAGAAAUCUCCAUCAGCUGUACAAAUGGCAAUUUAAAUACAUUUAACUAUGUGCUAAUAAUCUCAUAAUACAAUUUAUCAUGUAUGAUUGGCAGAAGAAAUUAUUUGGGGCAAAAGCUAUGAUUGUAUUGUUGUAAGUUAUUAUGAAUGCUGGGCAGUGUAGGGCAUGGCACUUGCUACCACCUCCCAGAAAUGUGUAAGGGCUGUUGAAGGUGCCUUGUUCUUCUUUCUUCUUCAAUAUAAGCAAAGCUAUUUAUAUCAUAAAGCUGAAACUUGAAAUUCCACCCUUGCCUAUUCUUUUUCCUCAGAAAGAUGUCUUUCUUUCUAAGAAUAUAUUGCACUUAAGGAUAGGAGGUGUCUCCUUUGGACGUCUAUGUGCCAAAUAUGUGUUGUAAAUUACUUUUGUUUCUCUUAAUAACCAGGGGUGAAGUUCUCAACAGUAUUUGCUGAGGAUGGUACAAGAUUUAAGAAGAAAACAUAUUUUUACAUCUUUCCCUUUGGAGUGCAGUGGUGCUAUCUCAAUUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCGAGUAGCUGGGACUACAGGCGCUCGCCACGACGCCGGCUUAUUUUUUUGUAUUUUUAGUAGAGACGGGGUUUCGCCGUGUUAGCCAGGAUGGUCUCAAUCUCCUGACCUCGUGAUCCGCCCGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGGCUUGAGCCACCGCACCCAGCCUCCAUUUCUUCAUUUUAGAAUGAUACUAUCAGGGAAAUAAAGAUGAAACGUAGAAACUUUGGUGAAUAAUUAAGAUCAUACACACAAGCAUAUCCAUGAAGUAAAAUAUUUUCUGCAGACCUCCCCUCACCUUUCCAAAUCAUAGUCAUAAAAUACUGAAAAUCUUAAGAAUGUUAAAAUGAUAUGAUGACCAGAGGCCUCGAAGUAAAUGGCCACUUUAUGGAAGACAUUACAUAAUUCUGUUGACAAAAUUCAUAUUUAUAUGUUCGUAGUCUUUGAUGACUGAAUAAUUACAUUGAAGUAGCUUCAUCUUACAGUGUAGUGUUGUCUUUUUAACUAUUAUUAAGAAUCUAUUUCAAGGAAAUAUAUGAAUGAUUCCACAUCCUCACAUUCAUUGAAUACUAUUUUUCUUUUUGGUAGUUAAAUCUUUUCAAACAAACUGAGUCCUCAGAACAGGAAUGACAAUUAUCAUGAGUUUGUUAUUCUAAUGCUUGACUUUUCUUUUCUUUUCUUUUCUUUUUGGUUCUGAAAACCCAUUGACUUUCUGAAUUGAAAAACCUAGCUCCGGAGAAUGUAUCAUUGAACUUAAAUAAAUUUGUGUAAAUAAUUAUAAACAUAAUGGUAAAUUUUGGCCAUUGUCUAUUAUAAUACCUACAAACCAUUAUUUUUUUGUUCAAUACUUGGGCAGGUAGGGGAAUGCAUAUUGUAGAACUUUGUUAAUAGAGAAUCUUUCUGGAAUAGAUUGAUAAGUAUCCAAGAAGCACUUGGACAGCUUUAAACAAAAAUGGCUCCAGAUUAUAAAUGGAUUACUUGAUGGCAUCUAUACUCCAAUGGAUCAGUCUAGAAAUGUUCCAUUAGUCAAUUAAAAAGGAGACUUUGGAUUCAGUAAGGCAUUAUUACAGAUUGAUGGAAGGUGAUUAGAUAGGAAUAUCAUCAAUAGCUUUUACUUUAAAAGAUCAUAUUUUAUUUUGCUUUUUUUAAAAAAAAAUUUAUUUAUUUUGAGACCAGGUCUCACUCUGUCACCCAGGCUUCAGUGCACUGGGGUGAUCACAGCUCACUGAAGCCUUGGCUUCCCAGGCUAAAGCAAUCCUCCUACCUCAGCCUCCAGAGUAGCUGGGACCACAGGCGUGUGCCUUCGUGUCCGGCUAAUUUUUGUAUUUUUGAUAGAGACAGGGUUUCACCAUGUUGCCCAGGCUGGUCUCAAACUCCUGAGCUAAAGUGAUCCACACACCUCUGCCUCCCAAAGUGCUGGGAUUAGAAGCAUGAGGCACCGUGCCUGGCCUUUAUUUUGCUUUCUUUACUUACAACAAUAAUCCAAUAUAUUAGUGUAUAUACUAUAGUGUACAGCACUUUCAUAUAUAUUACUUCAUAUAAAUCUGCAUGAGCAUAUUUACAAUGGGAAAAGUAGACUAGAACCUUCAAAAAGUUAAAUUCAAAUGGAAGGAUUCACAAAGUAAUAUAAUAAUUUCUGCUUGCAAAAUAUGGUGGAAAAACUGUUUCUUAGGGUACAGCACAUCAAGACUAUAAGAAUAUCCACAAUAAUCUUCCAAUUUAAUAUAUUCUGCUAUUUUCAAUCUUUUCUUUUUUUAGUGGGCUCUUUUUGUUGUUCUUGACUUAUUGGUGGUGUAGGGGGGCACUAGUUUCAUUUCAGAUAAAAUGUAAAAUAUAUAUGAUUUUAUAAGAUAAAAUGGAUAAUUUUUCUUUGGAAUGACAGAAGAAUGAACUUAAGUUUUUAAAAAAUAAAUGUUGAAGAAACUUUUCCUU

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications