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Homo sapiens (human) POT1 antisense RNA 1 (POT1-AS1) URS00007E4BE4_9606

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POT1-AS1: POT1-AS1 is a long non-coding RNA (lncRNA) gene located in the band 7q31.33, near the POT1 gene. It has been associated with increased risk of multiple myeloma (MM) [PMC8656811]. In cystic fibrosis (CF) parenchyma tissues, POT1-AS1 is up-regulated [PMC6916039]. It is also one of the top 10 significantly altered lncRNAs in CF parenchyma tissues [PMC6916039]. POT1-AS1 has been identified as a potential oncogene in various cancers, including gastric cancer (GC) [PMC9427269]. High levels of POT1-AS1 have been associated with worse prognosis in GC patients [PMC9427269]. Knocking down POT1-AS1 has been shown to suppress cell proliferation and inhibit the cell cycle in GC cells [PMC9355756]. Additionally, POT1-AS1 has been found to inhibit epithelial-mesenchymal transition (EMT) and promote tumor progression and angiogenesis in GC cells [PMC9355756]. The relative expression of POT1-AS1 mRNA is significantly increased in GC cells compared to healthy cells [PMC9355756]. The locus where POTI-ASl is located also overlaps with the protection of telomeres 7q31.33 region where both lncRNA gene and protection of telomeres 7q31.33 region where both lncRNA gene and protection of telomeres are found[PMC8016107].

Genome locations

Gene Ontology annotations

Sequence

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ACGCAUGCGUGCAGGAUCCCUGGGCAUAGUCGCUUGUUCUCCGCCCGCGGUGGACCAGCUGCGUAACGGUUCACACACUGAUGGCGCCUGGAGGUUUGGCGAAAUACUGACAGGAUGCGACGUCAACGGGAGCGCAGGGCCAAGAUACCCUUUAUAUCAAACCGUCUAUCCUGGAGCAGAAAAAUCCUGUCUUCAUUGCUAUAGCUACAGAUUCAGAAAUGAGCAUGUAACAAAUUCAGGCCAAAGAGAGGUCCUAAGCUUCCCUGAUGGUAUUUGGCAUCUGUUUUUAAGAAAAGGAUGAAGGCCGGUCACAUUGGCUCACGACUGUAAUCCCAGCACUUUGGGAGGCCCAGGCGGGCAGAGGACUUGAGGGCCUAAACCCGGCCAACAUGACGAAACCCCAUCUCUACUAAAAAUACAAAACUUAGCCAGGCGUGGCAGUGCUCACCAGCUACUUGGGAGGUUGAGGCACAAGAAUUGCUUGAACCCAGGAGGCAGAGGUUGCAGUGAGCUGAGAUUGUGCCACUGCACUGUACUCCAGCCUGAGCAACAGAGCAUCCAAGAGGAUGCUGAUGCUCUUGGCAAUGGAAAUCAGAGAAACACUGUUCCUGAAAGCUUCUGUCACUCAAGAAUCCAUGAAACAUUCAUGAACUUCACAUCAGAGUCCUCAGAAGGGAAGAUAGUGUUAAUGUAGAAUUGAUAACACAGAAUGCACCACUGCUGUGAUCCUUAUAUCUUGGCUGGCCAUUACCCCUCCACUUGGAAAUGAAAAAGAUAAACUAAUUGAAGCAGUGAGAAGAGAAAAAGGGAGAGGAAGGUUCCUCUUUGCCUUCAACCAUGAGUAACAGCUCCCUGAGGCCUCCCCAGAAGCUGAGUAAUGCUGGUGCCAUUCUUACACAGCCUGCAGAACCAGGCCAAGGACAAUUUGAUGCCACCAUUUCUUCUGGAUCAGUUACCAUUAGUGACCUAUAAAUAUGGUGAAAUAAGUUACUAUUACCCUGAGGCAGCAAGGAUUUUAGGACUCAGACUCCGUCUUUCUGCCCUUCGUCCUAUCUCACCUUAAUGGAACGGAAUGCCUCAGUACAUUUUGUGACAACCUAUAUAGCUUGAUGGGUCUGGGAUACACGUGCAGGACAUGCAGGUUUUAUUACAUAGGUAUACAUGUGCCAUGGUGGUUGCUGAACCUAUCAACCCAUCAUCUACAUUAGGUGCUAUUGUGGAGGUGCAUACCCAACAGUUUGAUAAUGUAGAGGAAGUGAUAGCUUUGUCUCGUGGAAUCUGGGUCGACCUCACAGAGGAGCUGUUAUUUGUUCUGGAUAUUGAACAGUGACAAGGAUUCAGUGGGAGAGAAAGAGGCGAGGAUUUUAAUGCAACUUGUUACACAAGAUGAACCCAAACAUAUUUGACUUUUUAUUUUCAGAAAAGCUUAAUACAUAGUUUUGAAUAUGGAUUGUCCCACAGGAUAAAUGCAUGAAAAAAGUUGGAAAAGAGAAAUUGAAUUACAUCCUAAUUGUAGUGUUUUCUCAGGCAGAUCAAUUUUAGAAAGAGAACAUUGACUUGGAAAACUGAAGAGUAAUUAUUCUAAAACGGUUGUAACAGUUUACUCCUUUUAUGUUUGCAAACUUCCAGGAUUAGUGAGUUGCAUAAAGUCACAUAAUUUAUUGCGUUGGUGCAAAAGUAAUUGUGGUUUUUGCCAUUAACAAAACCGCAAUUACUUUUGCAUCAGCCUAAUAUAAGUGAAUAAAUUAAUAUUAGAACACAGGUCUAAUUAAAAGGUUCUGCUGUGUUGUGUCCUGUGAUAACACAGAAAACAAACAAAUGGAUAAUUACAGAAAAAUUUUGGAUAUAAAAUUAGCAGGUAAUUUUCUCCCUCCUUUCCUUCCAUCUUUCCAUCCUUCUUUGCUUCCUUUGCUUUCUUCUUUUCCUUUGUUUUUUGUUUCUCUCUCUCUCUUUUUUUUUUUUUUUUUUUUUUUUUGCAAUUUGGAGAAGGAAGUACUUUAAAAGAAAAGUUAAAAGGCAGACAUAGAUAGCAUGAAGCCUAAUUGCAAGAUCUUUUUCAAACAUAUUAGUUUUAGGAAAUAGCACCUGAAUUUAAGUCCCUUAAAAUUGUCUAUGUCUUCACGUCCAAGUCUCUAUAUUUGCAGGGCUGUGUACAAUCUAGACUGAACAUGCUUGACCUAAAAACAGAAGUAAUACCUGGGGCAAAGCACGAUGUGCACCACAGUCUUCUCUCUUUAGUGUGUUAAGAUAAAGUUGAUUCCCAGAGUAGCCUGCCAUCACUAACUCUGAGGGAUGGUGGGCUAAUUUUGAUAGAAGGAGCAGAGGUGGUAGUUAGGAGGAAGGUGACUCAUCAUCAUUGUAUCAGCAGGCAUUGAUGACUGGAAAUAUCAGGGGGCACAGCCUGAAAGAGAAUGGCUUAAUUGGAAUUGAUAGUGGGAACUUGGAAAUCAAUACAUAUGCACUGAACAGAAAAUGGUAUGCUAUAAUCUACUAUACACUGUAUGUGAAACCCAAGCUCCAAAUUUUUCGGCCCAUGCAAUGUCCAGUAAAAUUUCUCUUAGUUACAUUAUAAUUGCAAUGUACAUGUAUUUGAGGAAAAAAAAAGUGAAAGAAAAAGUAACUAAAGAAAAGUGGAAAUGCAAAACUUUGUUUUUAUUAAUGUUAAAAUUUAUUUUGAUCAACUUGCUAUUCUUAAAAUUGACCAAUCUUCUUCCCUUCCUUGCCUCUUCCAUGGUUUAUAGGAUUAUUUUUCAGGGCUGAUCAGUUGGUGUUACAUGUGACUACUAUGCUUAAUGCUAUCUGGCUUCUAACUUUAAGCACUGAAAAAAAGUCCUUCGUAUUUCUCAGUGUGUGAUUGAACUGAGAUGACCAUCCUAAGCCUCCUCAUUACAUAAAUCCUUACCUUCUCCAGAAGCAACGAAUGGUGUUGAGAAUAGCAUAUGUUACUACUCAGCCAUAUUCCAUAGCCUUUUCUCCAAGAUAUUUUUCCAAAGUUGCCCCUUUUCUGAAUCCCUUGCAAGCAAACAAACAACAAAACAAUGGGUAAUAAAAUAAUUGUUUAACUUUCAUUUAUAUGCUCUGAGAUUGAUGUGAUUUUGAUAAAUAACUAUAUUAAAAGACAAAUGGGAGUGGUGAUUUUGUGAAAAGCCCAUGCCUCUGCCCAUGGAAUAUGUGGCUUGGCCUGGAGCUCUUAUUUUACUUAUAUAUUUCUAAGCAGAAUUAUUCAAGAAUGUCUCUUAUUACAGGUCUUGAAACUUGGACAGCCAACAGAAAGGAAGCUAAUAAAUAAAUUUGUCAGAACACGAUUCUCAGUUUCACUUAUUUUGAAUUAAAGGUAACCUGGAAAAUGGAUUAGGAAAACAGCCUAUAAUCAGAGGAGUGACCCCAGUGAGACCCUGUCAUUAAAACUUUAGUGUUGAGCCUGCAAACCUCUGUUCCUCUGAUUAGGCAAUUUACUCCAUUUCCACCUUUCUGUCUGCCAAAACAUUUAGUGGCAAAACAUUUUCUAAUUCUCUAGACUCAUAAAAUGUUGUUUUGAAAAAAAGUAAAACAGAAUGGAUUACCUUUUUAAGCUGUCUAUCAUAAUGUAAUCAGAAAACAUGAGGGAUUAAUAGAUAAUAUUGUAAAGAGGCAAAGGCAGCAGAUGUUAUUUAGAUGAGCAGAAGGUCACAGACCUCUGUUGAGGAUUGAAAGCUUGAGGUACGUGCCUUUGUUCCUCAGUGUGUGUGGAUCAGAGUGAUUACUGAUAUCAGUUAGCAACAUGGUGGAGGGGACAAACUGGGGCUGCAUUUUCACUAUGUUUAUUAUUGCUCAAGGUCAAAAAGUGACUGUGUAGUGCCUCAGUUUUUACAUCUUUGUGUUAUCAAUAUUUUUUUCUAUUACCUUACAAGUUUAUUUUGAUGCUGUAAUGAUGAGACAGUGUUUUGAAAAGUUCUAAAUAAAUAAAAGGGUAUUCUCUAACUUUUAAAAAAAAAAAAAAAAAA

Taxonomic tree

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