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Homo sapiens (human) gastric carcinoma proliferation enhancing transcript 1 (GHET1) URS00007E3B8C_9606

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GHET1: GHET1 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including thyroid cancer, ovarian cancer, triple-negative breast cancer (TNBC), acute myeloid leukemia (AML), gastric cancer, and colorectal cancer. It has been suggested that GHET1 could serve as a molecular marker of thyroid cancer progression and a potential target for therapy [PMC8797618]. In ovarian cancer cells, GHET1 was found to interact with VHL, an E3 ubiquitin ligase of HIF1α, blocking their binding and potentially affecting tumor progression [PMC6504664]. Overexpression of GHET1 was shown to promote the proliferation of ovarian cancer cells [PMC6504664]. In TNBC cells, GHET1 was found to activate the Hippo/YAP signaling pathway and promote glycolysis proliferation and invasion [PMC9550190]. In AML cells, GHET1 was investigated for its role in cell proliferation, differentiation, and apoptosis [PMC7591997]. Upregulation of GHET1 has also been observed in gastric cancer and shown to promote cell proliferation by increasing c-Myc mRNA stability [PMC6822487]. Additionally, GHET1 has been implicated in cisplatin resistance in gastric carcinoma [PMC7659041]. In colorectal cancer cells, silencing of GHET1 attenuated cell proliferation and invasion [PMC8351361]. The expression levels of miR-105 were also investigated when manipulating the expression levels of GHET1 in NB4 and HL-60 cell lines [PMC7591997].

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Gene Ontology annotations

Sequence

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AGCCACCGCAAGGUACCAGAGAGCCGCCCAAUCUGCGCUGGCCUCCUUUAUCUGUUUGCUGUGUGACCCUCCGGACAGCUCUGUGGGACCUGGAGGAAACUGUGAGCCCUACAGAUAAAGUCUGUGCUUCCAGCGUCGGUAAAUCCCAGCAAGCGCCACUACCUGGAGGCUGACACUUUCCCAUCUUGGCAGUCAGCUCCCUACAGAGGUGCUUCUCCCACUGCCCAAGAUCCCUGCCUCCUCCUUAAACCCCAACUGAUAGAACAGAAACCACCACCUAAGGAACGUGAAGGGGAAGCAUCUGAAACACCAGAAGAUCUUGGAUUGUUCCUGAGGACUUCAGAAUCUACAGGGACAAAAGGCAGAAGCAGGAAGUCCGAAGUAAAGAUGACUAAGAAAAGGCGGGUGGAAAAGAUUUCUGUGAAAGUGUCAGAGGCAAAGCUCUGAAAGACCUGAAACUCAUGCCGAAAGCAAAGAACAGCAAAAAGACAGUAGGGAUGUGUCUGGAGCAACAAGGAUCGGGCUGUUCCUGGGGCAGCCGAAUUCACAGCUCUGUUUUACUCCUAAUGGAGGAUCUUCCUGCUGCAGCGGCGAGUAGACCUUACUGUAAAGGUGCAGGCAAGGGGAGGGGAAGGGCAGGCAGCUGCCCAUUGGAGUUCACAUCUCCAAGCCUGAGAAAAUGUGUUCCUGGAUGCCCCAAGCCAAUGGAAAAGCAGAAUCAUUGACUAUGUUUGACUCCUUCUGGUACCUAGCACAGUAUCUGGGACACAGCAGGUGCUAUGUAAAUGUGUUGAGUGAAUGAAUGAAUGAAUGCCAUUGAGGAGAAUGAAUAACCCCAGAAAACUAGACAUGGGUAGAUGUUGUCCUAAUUUCAAAAGAGGGGAAAAUGAGAGUGAGAGUUUCAUAAAUGACAAUCUCUAAACGAUGUUGCUCUCUAGCAAAAUUCUAGAAUGGAUUAUUUUAAGAACAAAGCAGGUAAACAUUGGCAGCCAACUUGAAAUUAAUAAGAAAAAGGUGUGCGCCAGAAUAGUUUUAUUUCCUUUUGUUUUUCAUUGUACAGCUUGAUUUGACUAAGUUGUUUAUACCUUUCACUCUGCCUUUGCAUGCACUGGGGGUGAUCUAGUCUACUAUGUGGACUGGAAGUCCACCCAGUGGCCAGGCUCAGAGGCAGGGAAGGGGGGUUGGUGCCAUUCUGGGAGAGGAGGUUUCUGGGGCUGUUUCUCAGCCAGAUCCUGUCUCAUCUGUUUCCAACAACCCCACAAAUGAAGACACUGAAGCUGACUAAUCAAAUUGACUGAUGCCCCAAUAGGUGUCAUGAUAUGCAGUGAGAAUCCGGCAGGCAUUAGAGAUGAACAGCACGGGCUGCAGCCACAUUAUCUCAGCUUGAGUCCUAGUUUUCACCAGCUACUAGCUAGCUAUCUCUGGUCAAGUCACUUACCUUGCUUGAGCCUCAGUUUCUCCAUCUAGAAAAUGGUCAUAAUCGAAGUAUCUAUCUUAUAGGGUGUUGGGAAGAUUAACUGAGAAGCCACAUAGAGUUUACUGGCACAUUAAAAAAAGAAACUAUAAGAAUGUUAGCUGUCCUUUUGCACGGCAAAAGGAACAGUAAGCAGAGUAAACAGACAACCCACAGAGUGGGAGAAAAUCUUCCCAAUCUAUACAUCCGACAAAGGACUAACAUCCAGAAUCUACGAGGAACUCAAAUUAGCAAGAAAAAAACAAUCCCAUCAAAAACUGGCCUAAGGACAUGAAUAGACAAUUCUCAAAAGAAGAUAUACAAAUGGCCAACAAACAUAUGAAAAAGUGCUCAAUAUCACUAAUGAUCAGGGAAAUGCAAAUCAAAACCACAAUGCAAUACCACAUUACUCCUGCAAGAAUGGCCAUAAUAAAAAAAAAAUCAAAAAAAAAAAAAAAAA

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