hsa-mir-4259: Hsa-mir-4259 is a microRNA that regulates several target genes, including PDGFRA, RAC1, IKBKG, XIAP, and PPM1D [PMC9318750]. It shares the same target seed sequences as hsa-mir-4259 and hsa-miR-4715-5p [PMC5374554]. Hsa-mir-4259 is predicted to target the SPRY4 gene and transcription regulation genes [PMC5374554]. It has been detected in saliva samples but has not been quantified in plasma samples [PMC9481579]. Hsa-mir-4259 was not validated in a study that quantified several miRNAs [PMC9481579]. The miRNAs that were successfully quantified in the study included hsa-miR-92a-3p, hsa-miR-486-5p, hsa-miR-29a-3p, miR-486-3p, miR1505p, miR320b, miR4833p and miR3423p. Hsa-mir4259 was not detected in this study [PMC9481579]. Hsa-mir4259 is one of the selected miRNAs identified by hub genes [PMC9851797]. The pre-miRNA loop of hsa-mir4259 forms an rG4 structure [PMC7723054]. It was also detected in untreated extracellular vesicles (EVs) but at very low levels and was absent from cells and treated EVs [PMC10138286].