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Homo sapiens (human) HDAC2 and HS3ST5 antisense RNA 2 (HDAC2-AS2) URS00007E3953_9606

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HDAC2-AS2: Highly aberrant lncRNAs detected in our RB sEVs OXCT1-AS1, HPYR1, HDAC2-AS2, LINC02499, slc8a1-as1, ZFAND2A-DT, LINC01359, SCOC-AS1 have not yet been reported in RB [PMC9454787]. The majority of the DE lncRNAs identified in RB sEVs, including the top ones, belong to long intergenic non-coding RNAs (LINCRNAs): LINC02499, LINC02773, LINC01416 and LINC00994, whereas OXCT1-AS1, HDAC2-AS2, ACSL6-AS1, and SLC8A1-AS1 are some of the antisense DE lncRNAs that are able to control their own sense gene expression [PMC9454787]. Following are the top five differentially expressed lncRNAs in each infection category: AC114803.1, FOXD1-AS1, EGILA, UPK1A-AS1, and AC026954-3 are the upregulated lncRNAs by Mg infection; AL034417.4, DIO3OS, AC114284.1, AC079142.1, and AC006058.1 are the lncRNAs downregulated by Mg infection; AC053513.2, AC106739.1, AL021578.1, AC108448.3, and AC079298.3 are the upregulated lncRNAs by Mp infection; HDAC2-AS2, AL162274.2, LINC02323, AC232271.2, and SERTAD4-AS1 are the lncRNAs downregulated by Mp infection; AL360182.2, MIR210HG, AC015660.1, AL136131.3, and LNC00887 are the lncRNAs upregulated by both Mg and Mp infections; AC092807.4, PRKG1-AS1, AL133346.1, AC037198.2, AC019069.1 are the lncRNAs downregulated by both Mg and Mp infections, and AC134772.1 is the only lncRNA upregulated with Mg infection but downregulated with Mp infection [PMC10031284] [PMC10031284]. 1A), such as DIO3OS (maintaining monoallelic expression ) etc [PMC10031284]. In the end, 8 lncRNAs for prediction figured out: LINC00630, HDAC2-AS2, LINC01278, AL356599.1, AC114490.1, AL132639.3, FUT8-AS1, and TTC28-AS1 [PMC8221355]. The signature score of these 8 lncRNAs was counted out according a formula: signature score = (0.22636 × exp of LINC01278) - (0.26743 × exp of LINC00630) - (0.21030 × exp of HDAC2-AS2) - (0.20700 × exp of AL356599.1) + (0.32054 × exp of AC114490.1) - (0.23411 × exp of AL132639.3) - (0.29040 × exp of FUT8.AS1) - (0.29665 × exp of TTC28.AS1) [PMC8221355]. Additionally, LINC00630, HDAC2-AS2, and AL356599.1 were together in the brown module, which had a positive correlation with WBC count at diagnosis (cor =0.4, P=3.7e − 45), first event of relapse (cor =0.37, P =12.1e − 38), BCR ABL1 status (cor =0.35, P = 2.8e − 34), and survival time (cor =0.31, P = 7e − 27) (Supplementary Figure 5A–5D) [PMC8221355]. Among the 9 million expressed quantitative trait loci (eQTLs) identified in the DG-GCL, expression of 15 transcriptional signatures associated with schizophrenia risk loci were identified, including PSD3, MARS, NLGN4X, GRM3, SEMA6D, MMP16, THEMIS, SATB2, CACNA1C, KCTD18, PRKD1, HDAC2-AS2 [PMC10020196].

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UUUAAUGUUACUGCUCAUACUCCAAAUUAUAGAAUGCUUAAGAUAAUUAAAUUAUCUGACUUUUAUAAUUCACUACACGGUGACCUCAAAUUUACCUCAUUAGAAUAUUUAGUACUUCUGCACUUCUCCCACUUCUCAAAGUUUUCCCAUACCAGGAUUCCCCACCACCUAGGAACAGCCUUUGCAAGAUACCAAUGCUCUCUAAAUCCCCAAAGCAGGGUCUAUUUCCUGAUCGAACAAAGAGCAACAAAGAAGUGGGUGGUAACCACCUCUCUGAGGCAAGCCAGGACCCAUGGAGUCUGAUCUACAACACAAGCAGUAGCAGUUCCACAUCUCCCUACCACCUCUUAUUUCCUACGAAGUCUUUCUGCCUGAAACUGGAAAACCCGAACUAUUAUUGAGGAAGUGAAGCCCUUCCAUUUGAAUCCUGAGAAAGACGCGCUCAAAGAACCCAGCGAACAAAGGAGAGGGUUGGAGCCCACGCAAAACAUGGGUGUGAUAAAGCCACACGCGACCUGAGCCCCCACCCUCAGUAACUACUCUCCAGCGCCCACCGGGAGGAGGGGUCCGGGGAAAGGAUUGGCAUCCUCUGCUUCUGCAGAAAACAUGGCUACCAACAGCUUCUGUAUCCACCUGCGGAGGAGACUGACUGCUCUGUUAUUCCCCCAGCAUCUGUGAAGAGGCUCUGACUGGCUAAAGUGUUGGAAGGAGUCUGUAGCUUUAGGGGAAGACAGAGCCACAAGAUGGAAGGAGCUUGGAUGUCUGAACUAUUCCAUGGAGAAAAGCUGCAGCCAACGAAGAACACCUGCAAUGGACUCUUAACCUGGGGGUGACGACAACCACUGAAAUAUGCUGCAUCUUAGUCCAGGGAUUUUUAAAGUGUGGUUCCUGGAAGAGCUGGAUCAGAGUCAUCUGUGUUGAUGGUUUAACAUAAAGAUUUUCGAGCCCCAAGACUCAAGUAGGACAAGGAAUUUGAAUUUUUAAGCAGCUCACCUGACUUGUCUGUCCUCUAAUGUCUGAAGACAUCUGACCUCUGCUCUUUCAGUAAAAGCAACAAUGGUUUUAUGAGCAUUGUCGUCACAUCUCUCCACUCAAGGGAUCCUUCUCAUUUCUCCCAGCUGAGGUCACCCACAGCUGCUGCUUCUAACUGCUGGCUUCCAGCCUGCUGUCUGCCAGCUGGCUCUACCCUCUCCUAUAACACGGCAGAGAGUAGCUGUGGUCUCCUGCGUGCUCACCCUCUGCUCCCUUGGUCCUGCUCCAUGCUUUGGUCCUGCACUUAAAUUUUACAAGCAUACUCUCUUUCUCUUAAGAUGAAGGAGCUGAGGCUGGAGAAGUUAAGAGACCCCUGCUAGAUAGGAAGGCACGUGAGAAGUAUACUGCUCUGUCUCCUGUGGAGUAAAAAGACUUUGGCGUUCUCAGAAGAAAACCAAAUGAGAUCACACGAAUGAGACUGCUGGCUGAAAUCUUUCAGAGACAAGGUUCAAGAGAGCAAGCAAAACAUUGCACGACAAUGAACAGAUCAAGGUAGCCACUCCCAGUCAAGGACUGUAUGAGUUGCCCAGAGCAAGACCUUUUAGGAUAUGGUACAUAGCUGGGAGCCUGCCAACUCCUGAUUUUGUCAUUACCCUCAGAACUCCAGAAUGUAAGCUCCAUGAAGAGGAUGCACCUCCAACAAAACAAUUCUUACAUGGAAUCCUAGAGUCUUUGGAACGUGGUUUGAACACCACCAGCUUUGAGAAGGAAGAGAAAAUCCAGAAGUCAGAAGUGGACCAUGUUGAUCAGGAUCCUACACCUUCCAGUUCACUGGUGAAUAACUUCAUAUUCCUGAAGUUAAGAAGCCUGCCCUGAUGCUCAUGCAGUUACUUUGAGCAAUGACCAAACAGAGAGAGGAAGGUAAGUAGUAUUGUUUUCAUUUCUUUAAAAACUUCACUAGGAGGAAACCCCAAGGUAACAAUGACAACAACAAAAAUCUAUUGCAACAUAAUUGAUAGCAAUAAAACCUUUUUU

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