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Homo sapiens (human) ovarian adenocarcinoma amplified long non-coding RNA (OVAAL) URS00007E36BD_9606

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OVAAL: OVAAL is a long noncoding RNA (lncRNA) that plays a role in cancer progression. Silencing of OVAAL leads to a reduction in the activation of the RAF/MEK/ERK cascade, as evidenced by decreases in p-MEK, p-ERK, p-MSK1, and p-RSK1. This effect is similar to the knockdown of STK3 in ME4405 and HCT116 cells [PMC6294934]. OVAAL expression is also relevant to cancers in vivo, as it is found in clinically derived samples [PMC6294934]. OVAAL and TRMP are lncRNAs that suppress internal ribosome entry site (IRES)-dependent p27 translation. TRMP-S, a shorter variant of TRMP, represses p27 expression through both transcriptional and posttranslational mechanisms [PMC9982580]. OVAAL shows the highest hazard ratio (HR) among lncRNAs when correlated with the survival of TCGA GC patients [PMC9459305]. Additionally, OVAAL regulates c-Myc posttranslationally by stabilizing c-Myc protein levels [PMC6294934]. These findings suggest that OVAAL plays a significant role in cancer progression through its involvement in various cellular pathways.

Genome locations

Gene Ontology annotations

Sequence

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CUUGCCACUGCCAUGUAAGAAGUGCCUUUCACCACCCCCACACCCUGCCAUGACUCUGAGGCCUCCCCAGCCACGUGGAACUGAGGCAGCUGUAUGGAGGCCAAUAUGCAGACAAGGGAAGUAACUCAGGCAUUUUGGGGGAGAGGUACAGAAAGAAGAGAAAAGACUGAACUGACUGCUGUUCUGAACAAGAACUGUGACUAUAUGUGGUACUCCCAGAAUGCUGGUUUCCUUUCAGACCCAUCAAGUGGCCAUCCUAUUGGCUUGGACUGAAGACCCCCACUGGAGAACUGUCUCUGCAGCCUAUACUGAUGACACUGGCCACUGUCCAGGGCUCCACCCCAAGGAGUCCAAGCCCCAGACAUUUAGCCUUAGAGAGAAUCCAGAUUUUGCAUUUCCAGUGCAGGGAUUGAUGGAGCCUUGUGUAUCAAAGUGCCAAUUUCUUUCUAACAAGCUAGGGAGGAUACCGUUGACAGCAGCAGAAAGGGGUAGCAGUGGUUUGCUUUCCAAAUGGUAAUAAGAAGGGCCUGGCAGUGGCAACCUGUCCACGUAUCAUUAAAAAUGGACUCUCCUGCUUCGUUUGGAAUUCAACCCAAUGAACUUGAAUAAACUCUGGACAAUGACCAGCACAGAGCCCUAAGCAGGAUACAGCAAGAUUAUUUGCUUUACUCAUCCACUGAGUACCUACCAUGUGCCAAAUACUAUGCUAUAUGCCGAGUAUACACUGGCAAAUAAAACAGAUAUGGUCCCUGGAGCCUAUGAAUCUUACCCCAUCUAGCCACAAAUAAUAAAAAUAAGAAGAAUCUGAAGGACAAGUGGGACAGAAAUACUCAAGCAGAAUGAGGGUGAGAUUGAAGUCCCUGAACAUACAGUGCCCUUUACACUUGAUCUUAGCCAAAAGGCCGAGAAGAGAUUACAGUGCUUUUUAAAGGUAGCAUUUCACCCAGCCAAUAAUCAAUCCCUUUGGCCUUCUUGAGGUGCAAGGCCACACACUCAAAUUCUUUAAUCAAACAAUAGGCUAGUGCAAAUGGAGCUAUUUCUUAAACCCAGCUGUUUACACAGCAGCUACAAAUCUGUUCAGAAGGAAUCCCCCACCAUCCACAACUGUCUAUCGAGCAGAUGUGCAAGAGUAUUUGUCUCUCACCACCAGGGUUGCAGUCAGGACAAGAGAGCAGGUUUGAACGUCUUCGGCUCCUAGAACUGCACAAGCUGUGUCUUCAGUGCCCAGAGGCGGCUGCAACGUCUCCCCAGUUCUCCUCUCAGAACAAUGGAAAUUUUUUUUAGAGGCGUAAUAGGAAGGUUUGCAUUGAAUUAUUAAACAAUGGGUAUUGAAAAAUAUGUUUUCUUUGACCUCUGUACUUCUAGCUUUUACCAGUCAGUGUUUUCUUGUACCAAGGCUAAGAUAUGUAUAACACUGAAAUGGAUGUCUUCUUAUAUAAUAUUUUACAAGCUUUUGAAAACCUGUGCCCUUUAAUAAAUUUUAAAACGUUUAAAAAAAAAAAAAAA

Taxonomic tree

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Publications