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Homo sapiens (human) ZFPM2 antisense RNA 1 (ZFPM2-AS1) URS00007E33EE_9606

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ZFPM2-AS1: ZFPM2-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including gastric cancer [1], thyroid cancer [2], glioma [3], retinoblastoma (RB) [4], hepatocellular carcinoma (HCC) [5], and small cell lung cancer (SCLC) [6] [7] [8] [9]. Knockdown of ZFPM2-AS1 expression has been shown to impair cell proliferation in gastric cancer and thyroid cancer cells [1] [2], as well as induce apoptosis in thyroid cancer cells [2] [1] [3]. ZFPM2-AS1 has also been suggested as a potential diagnostic indicator for glioma [3] and a prognostic marker for RB [4] and HCC [5], with higher expression levels associated with worse outcomes in these cancers [4] [5] [10] [11]. In addition to its role in cell proliferation and apoptosis, ZFPM2-AS1 has been implicated in cell migration and invasion in various cancers including gastric cancer [2] and RB [4] [12]. Furthermore, ZFPM2-AS1 is involved in immune-related pathways such as antigen processing and presentation, Toll-like receptor signaling pathway, and RIG-I-like receptor signaling in gastric adenocarcinoma (GAC) [13]. The molecular mechanisms underlying the role of ZFPM2-AS1 involve its interaction with proteins such as macrophage migration inhibitory factor (MIF) to induce p53 destabilization [2] or hypoxia-inducible factor 1a (HIF-1a) to promote the proliferation and migration of HCC cells [8]. Overall, ZFPM2-AS1 appears to play an oncogenic role in various cancers and may serve as a potential therapeutic target or diagnostic/prognostic marker in these diseases.

Genome locations

Gene Ontology annotations

Sequence

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CUUGACCGCAGCACAUCCGUUUUCCUUACAGUAUGUAGUACGCAUUCUACCUUUUCCUACAAUGAAUCCACCAGCAGAAAUUCCUGUACACAUCUUAUCAACAAAGAAUUUGAACCUCAAAGAGUUCUGGUGCUGGUGAUUAUUAAGUUCUUCACACUUCUCUCAUAGUGGAGCUUAAGAUUCUCACUGUGUUACCUAGGCUGCAGUGCAGUGGUGCGAUCUCAACUCACUGCAACCUCUACCUCCUGGGUUCAAGCAAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGAGCUCAUGGUUUUUAAACAACUUGUGGUAAAAAUCUGGUGGAAAAGAUAACAACAGUAUAUGAUAUGGCAGAGUUGCACAGAAGAAUCAGAACAUUGUUUUAGAGAAACGUUGGGCAAUUAAUUAAGCCAGCUGAUUAAGUUUUAAAGAAGCUAAACCAUAUCAUGUCGAAAUCAGAGGAGCGAUGAAAGUGUGAGUGGUGGUAUUUCUGCUGUUCUCCCCCCUGAAGGCUUCUGCGAUUAGCUUCUAUGCCUUCCUUCCCUUAUGGGCAUUCAGAUCCAAACUACUUGCAACUGUAGACAAGGAGGAAGAUGGAACUUGGAGAAGACAUACAGGCUGAAGAAAAAAAAAUAUUUUGGAAGUGAUCAGCACAUUCUAAUUGACCAUGGAUGCUCUCUGCAUUCAUGUGGUAACCCAGGGAGAGUAUGGAGUGAAAAGAGGAUCACCAAAGAAACUUGGGGAAUUACACACUAAUAGUGAAGAACAGGUGGCACCUGAAAUCACAGAAAAUUUAUUUGUCCUCAAUGCAAAGAUGAACUAUGAAGAGCACUUUAUUGCGUUUGAAGAAUAUAGGAAUGAUGAGUGAAAUGGUGAAGGAAGUGGAUAAACAAUGAUGUAACGACUGAGCGUCAUCUUGCAACUGAAUAAGCCAGUGAGGAACUUGGUAAAUUUGUUGAUUAUAUUUAGUUUUACAAUGUUUAAUUCUUUAUUAUUU

Taxonomic tree

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Publications