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Homo sapiens (human) hsa-miR-6127 URS000075F03F_9606

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hsa-mir-6127: Hsa-mir-6127 is a microRNA that has been validated through functional studies to bind to a circRNA, hsa_circ_0045272, and act as a sponge to downregulate apoptosis and IL-2 expression [PMC8599985]. It has also been found to target multiple genes, including UBE2D3, in the context of gestational diabetes mellitus (GDM) [PMC8145272]. However, the specific role of hsa-mir-6127 in cigarette smoking-related pathology has not been reported [PMC8882369]. Hsa_circ_0045272 is suggested to negatively regulate T cell apoptosis and IL-2 secretion through the adsorption of hsa-mir-6127 [PMC9972402]. In the context of GDM, UBE2D3, PAK2, DDB1, DVL3, PSMC4, hsa-mir-6127 (among others) have been identified as novel biomarkers for disease progression [PMC8145272]. Additionally, there are 43 co-targeting miRNAs that include hsa-mir-6127 in their target list [PMC7607069]. Overall, these findings highlight the potential role of hsa-mir-6127 in regulating various cellular processes and its relevance in different disease contexts. However, further research is needed to fully understand its mechanisms and functions.

Genome locations

Gene Ontology annotations

Sequence

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UGAGGGAGUGGGUGGGAGG

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This sequence is found in 2 other species

  1. Macaca mulatta mml-miR-6127
  2. Pan troglodytes ptr-miR-6127
Publications