v24

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Homo sapiens (human) long intergenic non-protein coding RNA 977 (LINC00977) URS000075EF7A_9606

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LINC00977: LINC00977 is a long non-coding RNA (lncRNA) that is up-regulated during lip and palate development and is not present in mice [PMC6494499]. It is located in the 8q24 region and is approximately 358 kb and 636 kb downstream from the nearest genes LINC00824 [PMC4874577]. LINC00977 has been found to be downregulated in various conditions, including in prostate cancer [PMC8957827] and breast cancer [PMC4991477]. It has also been associated with alterations in other genes, such as GSDMC, in breast cancer [PMC9428000]. The expression of LINC00977 has been found to be affected by the accessibility of enhancers E1 and E2, with reduced accessibility leading to reduced expression [PMC8409102]. Motifs for putative regulatory elements at the LINC00977 locus have been identified using the JASPAR reference database [PMC8409102]. Overall, LINC00977 appears to play a role in development and disease processes, particularly in lip and palate development as well as various cancers.

Genome locations

Gene Ontology annotations

Sequence

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UGUUGGCUGAGGCUCCCUCUUGCCGGCUCCUGCUCUUGAAACACACCCAAGUGCAAUGUUCAAUCAUCUACUUGUUUCCAAAGUUAUUUGGGUCAGCAUUUUCCUCCACCCACCACUUAAAACUGAUUUGUUUCAUACAUUUGAAAUGUAUGAAAAGCCAGAAAUCCAGGACCCACCCUGGCCUGCUCCCUUUUUCUCACCUACUGUGUUAAGGAUAAGUCAAUUGAGCUUCACUUCUCUAAUUGAAAUCACCGUGCUGAUGGAGUCUGUCUGUGGAAAUGAAAGGUGGCUACCAUAAUCUGUUGGGAGUUGAAUUAAUCCUCUGGGAGUGAGGCUGACCUAAUUACUCAGAAAUACUGGGCUUGCUUUCAUUCUGUGGAAUACAGCCAUGAGAAAGAGGCCAGCAUGCCAUUUCCUAAUCUUUUCUUGAAUUGCCUGAAACUCACCUAACAUGAAACUGAGAAGCCUUUUCAUUUGAAAGUGGUAUUUCUUAUGUUUUUUAUCUUUUUGCUUGAAAGUAUUCUUAAACUAAAGAAAGGAGAAACAGAAAAGGUGAAGAAGCCAAGAGGCUGGAGUUUCCUUUUGAAUGGAUAUUCAUCCAUGAAGCUGUUGAUUCUGUUUUUCUGUUCCUCCAGAUGUCUACACUUUUACCUCUGCUUGCCUGAUACAACCACCACCAGUCACCUCACAGAAUAACUCACUCCUUAAGAAUCUGAUCAGGAAUCAGCCUUCCCUGAUCACAAACACUGAGUUUAGAAGUCCCUCCACAGUGUCCCCCGUAACCCUGUGCUACCUCACUGCCUCAUAGUUUAGUGCCGUUUGUGUACAUGCCUAUCUUCGUCCAUGGAUCCAGAACAACUUGUAAAAAUGACUGUACUUAUCACCUUCAGUAUUCAAUGACUAAACUAUAAUUUUAACAUAUCUGGCAGAAUGAAUCACUUGGGGAUUUCUGCCAACACUACCAAUAUAUUACUCCUAAUUUGUAAUUAUUACUUAGCAUGGAUUAUAGUACCGGCUGUUGGAGAGCCAAUGUGGCAGACCCUAAGUGGAAUAAAAUGUCAGUAGCAGUCUAGGAGCAUAUAUUUAUUGGAAUAGAUCAUUCAUUCAUUUGUUCAUUAACUAAUUUGUUCAUUAAAUAAACAUUUAUUAAGCAAAAAAAAAAAA

Taxonomic tree

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Publications