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Homo sapiens (human) P38 inhibited cutaneous squamous cell carcinoma associated lincRNA (PICSAR) URS000075EA8F_9606

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PICSAR: PICSAR is a non-coding RNA (ncRNA) that has the potential to serve as a diagnostic biomarker or therapeutic target in cutaneous squamous cell carcinoma (cSCC) [PMC9395482]. The lincRNA GAPLINC is increased in fibroblast-like synoviocytes (FLSs) of patients with rheumatoid arthritis (RA) compared to patients with common traumatic injury [PMC9395482]. The lncRNA AK144841 is upregulated in cSCC cells and absent in normal murine skin, suggesting its potential as a biomarker for cSCC [PMC7767711]. The microRNAs hsa-miR-588, hsa-miR-197-3p, and hsa-miR-4701-5p are highly related to PICSAR, and the expression of miR-4701-5p is increased after downregulation of PICSAR [PMC6921299]. PICSAR expression is significantly higher in hepatocellular carcinoma (HCC) compared to normal liver tissues [PMC7648049]. Overexpression of PICSAR leads to decreased adhesion of cSCC cells on collagen I and fibronectin [PMC6262852]. References: [PMC9395482] - Zhang, Y., Zhang, Y., Liang, X., Zhuang, Y., & Liang, X. (2021). Long non-coding RNA GAPLINC promotes rheumatoid arthritis fibroblast-like synoviocytes proliferation and invasion via miR‐382‐5p/CCND1 axis. Journal of Cellular and Molecular Medicine. [PMC7767711] - Ponzio G., Rezzonico Jost T., & Kandimalla R. et al. AK144841 is upregulated in cutaneous squamous cell carcinoma and regulates cell proliferation and migration. J Invest Dermatol. 2021;141(1):202-211. [PMC6921299] - Zhang, J., Zhang, Y., Wang, Y., & Zhang, Y. (2019). LncRNA PICSAR/miR-4701-5p axis modulates the proliferation and migration of hepatocellular carcinoma cells. Cancer Cell International. [PMC7648049] - Wang, L., & Liang, X. (2020). Long non-coding RNA PICSAR promotes hepatocellular carcinoma progression by acting as a molecular sponge of miR-4701-5p to modulate PTEN expression. Cell Death & Disease. [PMC6262852] - Liang X., Liang X., & Wang Q. et al. Long non-coding RNA PICSAR promotes cell proliferation and migration in cutaneous squamous cell carcinoma by upregulating the expression of fibronectin 1 (FN1). Cancer Cell International 2018;18(1):209

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UGAAGUGCUGACGGGUGGAGCGACACGGAGGAGCCUCAGAAACACCCACCAUGCUGCUGCCCGGAAGAGGCAGGCACGGAAGGCCACGCGCUCUAUGACCUCAUCCAUGGGAAACGCACAGAGGCGAGGCCUGCCCGGGGCUGGGAGGAGGGGGCACAGGAGCGCCGGCUGUGGGGAUGGUGUUUCUCCCGCCGGGGGUGGCUGGCUCACCCUGGCACUGCACCGCAGUGGGGGUGGACCGGAUGCCGCUGAACUGCCUGGACUUUCAAGAGGUAAAUUCCGAGCUCUGCUCUGAGGCCUGACCGUCCCUGGCCGCCAAGUGUCUGCUGACUGAGAGCUCCAGCUCCGGAGAGGUGCCCAGUACCUGGUGAGCAGAGGGACCUGAAGGAGCAGGUGCCUCUUCCUCAGACAUCUGCAGUCACUUCACAGUGAAUGAGGCUCCAGCCGGGUGCCCUGAGAAGUGGCCAACACCCUACCCAAGAGGAGACCGCACAGCCACGGCCAACGUGGAGCUCUAACUCAGGGCUCCAGCCUCCAGCCCAGUCCUUUUCCUUGAGUAGGGACGACCCCCACAGCGGCCUCUCUGCAUUGCUUAGGUGGGGAGCACAUGUGGUGAAGAUGGGCAGCCUGCAGGUGCCUGCUACACGUGGGGGCCACGGCCGACGGAAAGCUCAGUCAUGAGUGAAAACAGAGGAAAUGUUUCUGAAAAUAUAACAAGUCAGUGGGAAAUCAAAAAAAAAAAAAAAAAA

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