MIR4802: MIR4802 is a microRNA that is downregulated by LPS/TLR4 interactions, leading to increased autophagy and enhanced cell resistance to therapy [PMC9315032]. In colorectal cancer (CRC), Fusobacterium nucleatum plays a role in chemotherapy resistance by coordinating TLR4-MyD88, miR18a, MIR4802, and ULK1/ATG7 autophagy networks [PMC9411745]. F. nucleatum downregulates miR-18a and MIR4802 to activate the autophagy pathway and promote chemoresistance in CRC [PMC9718533]. The bacterium also activates the TLR4/MYD88 and ULK1/ATG7 signals, which decrease the expression of miR18* and MIR4802, respectively, contributing to CRC cell proliferation and chemo-resistance mechanisms [PMC9959216]. Additionally, F. nucleatum promotes chemoresistance by activating the autophagy pathway through downregulation of miR-18a and MIR4802 [PMC8106554]. Overall, these findings highlight the important role of F. nucleatum in controlling CRC chemo-resistance through its interactions with microRNAs (miR-18a and MIR4802) as well as the TLR4/MYD88 and ULK1/ATG7 networks [PMC9959216].