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MIR489: MIR489 is a microRNA that has been identified in various studies as playing a role in different biological processes. It has been found to be differentially expressed in paired samples and shares similar regulatory trends with other miRNAs [PMC3398046]. MIR489 is necessary for maintaining the quiescent state of satellite cells by post-transcriptionally repressing the oncogene Dek [PMC6303387]. It has also been implicated in the regulation of quiescence in MuSCs [PMC9715903]. MIR489 has been shown to be downregulated in certain conditions, such as cardiac hypertrophy, where it is regulated by the lncRNA cardiac hypertrophy-related factor (chrf) [PMC7123062]. Additionally, MIR489 has been identified as a positive modulator of adult stem cell quiescence and is involved in the post-transcriptional suppression of the oncogene Dek [PMC6446479]. In breast cancer cell lines, overexpression of MIR489 leads to down-regulation of HER2 [PMC4951289]. Downregulation of miR200c and MIR489 has been associated with better prognosis, while upregulation of miR484 and miR4443 is associated with better prognosis [PMC7827149]. Furthermore, targeting MIR489 may have therapeutic potential for certain conditions such as kidney ischemia and cardiac hypertrophy [PMC8001091] [PMC6562440] . However, it should be noted that deletion or knockout of certain genes may not necessarily affect the expression or presence of intronic MIR489 or other miRNAs such as miR208.
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