v24

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Homo sapiens (human) CDK6 antisense RNA 1 (CDK6-AS1) URS000075E91D_9606

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CDK6-AS1: CDK6-AS1 is a long non-coding RNA (lncRNA) that is aberrantly hyper-expressed in blasts, including the CD34+ subpopulation, in order to meet high energy demands and promote drug resistance to evade apoptosis [PMC8591413] [Lapalombella, 2017] [Yoshida, 2015]. Targeting mitochondrial dependencies may be an effective approach to impact CDK6-AS1 Q4-AML cases [PMC8591413]. The expression levels of Linc0116, Linc00667, CDK6-AS1, FENDRR, and DIRC3 lncRNAs were quantified in tissues and blood samples using the qRT-PCR kit from GeneDireX (Taiwan) [PMC8466695]. The role of LPS (lipopolysaccharide) and CDK6-AS1 in cell viability was studied by stimulating cells with reduced levels of CDK6-AS1 using LPS and then detecting cell viability using the MTT assay [PMC8395588]. A positive correlation was observed between CDK6-AS1 and its target gene CDK6 (Spearman r = 0.38, p = 1.68 × 10−14) [PMC9100412].

Genome locations

Gene Ontology annotations

Sequence

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GGGCCCAGUCGCGUCGGGCCUCCCGAGGGGGCUGCGAGUGUCAGUCGGCUCUCCGCACGUGUCCGCGGCCUCGCGGAGCAGUCCACCCCUGGCUGGUUUCUGCUUCCACCUGCUGAUCUCACAGAGCUUGAUUUUGACACAAAGCAAGAUACUGAACAUUAACACCACCACAGAGGCCUACUAUGUGCUCCUGUCCCUGUUGUUACUUCCUCCAAAGUGUUGGAGGAGGGGCCUUGUGGAAGGUGAUUGAAUCACGGGGACGGACUUUCCUGUUGCUGCUCUUGUGAUGGAUUUCUCACAAGAUCUGGUUGUUUGAAAGUGUGUAGCACCUGCCACUUCACUCCCUCUCUCUCCUCCUGGCCAUGUGAAGACUGUGCCUGCUUCCUCUUUGUCUUCCACCAUGAUUGUAAGUUUCCUGAGGUCUCCCCAGGAGCAGAAGCCUAUACAUCCUGCAGAACUGCAAGCUAAUUAAAUCUGUUUUCUUUAUAAAUUACCCAGUCCCAGCACUGCAAGCUAUUUGGCAUAUGAAGGUCUUGACCUGAGAAAACCAUCUUGGAUAACUGCAGCAAGGAAAAGGAAAAAUGCAACACCUAGGAGAUUUCAGUAAACAGUAGAAUCAUGCCAACCUAAUCUGUGUUAAAAUGCUUGGAAUGUGGGAGCCGCUGAUGAUGCCUCUUGUCUGUGUGUCUGACUGAAUCCUUUCUUUUCUCAGAGCAGCAAAGCAAAGCCUGGGAACCAGGCCAAAUGCCUGCCACUUACCUUAAAUUGAUCAGCCACUUUGAGAUUAAAACCCCUGAAAGCUGCCACACCGUGAAAACAAGGCCUCCUUCACAUUAAAGGCAAAUUGCGACUUUGAAAAAAAAAAAAA

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Publications