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Homo sapiens (human) microRNA hsa-mir-3065 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-3065 precursor URS000075E912_9606

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MIR3065: MIR3065 is an important nonprotein coding regulatory gene that may play a key role in breast cancer (BC) development and heterogeneity among African American (AA) women [PMC5989404]. It is located in the seventh intron of the apoptosis-associated tyrosine kinase (AATK) gene and transcribed in the opposite direction from its host gene [PMC5989404]. MIR3065 has been found to be encoded in a region with high-level genomic amplification in various subtypes of BC [PMC5989404]. It has been shown to have a disparate expression pattern between normal breast tissue and breast tumors [PMC5989404]. The genomic region that includes MIR3065 also contains the brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) gene [PMC5989404]. The role of MIR3065 may be to suppress expression of oncogenes, as it has been found to have predicted targets that are likely oncogenes [PMC5989404]. Functional assessment is needed to understand the molecular mechanism behind the association between BC risk, particularly ER positive BC, and SNPs in BAIAP2 and MIR3065 [PMC5989404]. MIR3065 shares its genomic location with mature MIR338, but they are transcribed from opposite DNA strands [PMC5989404]. Additionally, a SNP within the precursor sequence of MIR4739 has been found near one of the top hits in MIR3065 but is not highly linked with it [PMC5989404]. Among TargetScan's predicted gene targets for MIR3065 are AT-rich interaction domain 4B (ARID4B) and RAB22A, which are involved in signal transduction and belong to oncogene families [PMC5989404][PMID:10138222].

Genome locations

Gene Ontology annotations

Sequence

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CUGCCCUCUUCAACAAAAUCACUGAUGCUGGAGUCGCCUGAGUCAUCACUCAGCACCAGGAUAUUGUUGGAGAGGACAG

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This sequence is found in 3 other species

2D structure Publications