MIR1976: MIR1976 is a microRNA that has been found to be associated with E. coli-induced vaginal infection in mice [PMC6783613]. It has been shown that the suppression of MIR1976 is linked to the infection [PMC6783613]. Bioinformatics analysis has identified CD105 as a target gene of MIR1976 [PMC6783613]. The administration of an adenoviral vector overexpressing MIR1976 resulted in a decrease in vaginal redness, indicating the potential therapeutic effect of MIR1976 [PMC6783613]. The expression level of MIR1976 was significantly decreased in vaginal tissues infected with E. coli, further supporting its role in the infection [PMC6783613]. Successful transfection of mouse vaginal tissues with the MIR1976 adenoviral vector was confirmed through fluorescence imaging [PMC6783613]. The study suggests that MIR1976 may play an important role in E. coli-induced vaginal infection by regulating CD105 and integrin αvβ6 signaling pathways [PMC6783613]. It is worth noting that the effect of MIR1976 on inflammation regulation and vaginal infection still needs further investigation [PMC6783613]. Additionally, previous studies have shown that MIR1976 may have prognostic implications for certain cancers and bovine infectious diseases, indicating its potential as a therapeutic target beyond vaginal infections [PMC6783613].