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Homo sapiens (human) long intergenic non-protein coding RNA 656 (LINC00656) URS000075E87C_9606

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LINC00656: LINC00656 is a long intergenic non-protein coding RNA that has been implicated in various diseases, including gastric cancer [PMC10113535]. In a study investigating the role of LINC00656 in chronic obstructive pulmonary disease (COPD), it was found that LINC00656 was upregulated in COPD patients and positively correlated with disease severity [PMC10113535]. Additionally, LINC00656 expression was differentially expressed in two clusters of COPD patients based on the presence or resistance of anoikis, a form of cell death [PMC10113535]. The study also suggested that LINC00656 may be an upstream regulator of tenomodulin (TNMD), as there was a significant positive association between the two [PMC10113535]. Furthermore, exposure to cigarette smoke extract (CSE) led to an upregulation of both TNMD and LINC00656 expression in airway epithelial cells [PMC10113535]. The study also investigated the association between TNMD and LINC00656 expression and infiltrating immune cells, suggesting their potential involvement in immune function and the anoikis phenotype [PMC10113535]. However, no relationship between LINC00656 and COPD marker inflammatory cells was observed [PMC10113535]. Overall, these findings highlight the potential role of LINC00656 as an upstream regulator of TNMD and its involvement in COPD progression. Further research is needed to elucidate the molecular mechanism and biological role of these molecules in COPD.

Genome locations

Gene Ontology annotations

Sequence

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AUUUUACAGAUGACACACUAAGGCGCAAGGCAGCUGCACAUCCACGGCCAGCCUCGUUGUCUUCAGGGAUUUGUUCAAAGUUCAUUCUGAAUUGUAAGGUAACCACUGCAGAACACGAGCCUUUCCUGGGUAUGUGUGGUUAUUUCUGCCCUUCACGGUCCCACUCAAGUCCUGCCUCCCUCAGGGAGACCUCCCAGACCUCACCAAGCCGUGGGCACGUGGACCAGAAGCCGUGGACCCCAGAGGCUCAUUUAGGGAUCUGCUUUCUGAACCCAGGUCCUAACAUCUGCACUGCAGCGAGCAUUUCUGGUGCCUCAAGUGAGUCACUCCAACUUCCAGCUCACUGAGAGGCGAUGGAGCACUGAGUGCCAGCAUCUUCCAGCACCAGAGGAGCUGACUCUGAAUAGACAGCUCGGCAGCGGCCUCAGCACAGAGCAGGGGAGCCACCAGCCACAGGCAGCCACUGAGCCCUUGGCAUGUAACCCGGUAACCCAUGCAACAGAAGACCUGAGCGUCCAGUGUUGCUAGCUUGAAGUAACUUCAGUGGUGUUCCCCAGCGUUUUUCUCAUCCCCCUCCCUUCCCUUCCCCUACAGCUUUCUUCCUCUUUCCCCUCCUUCUGAGUCUUUCGUCCCCAGUCCUGGGAACCUUUUUUCUGACUUGGUGUUUUCUCCUGAAUGCCUCCUUCCUGGCCCCCUAAUCAGAAAUGCAGAAGCCACCUGCCCCACACAGGGGGCCACUUUCCCUGCAUCUGGCACUCACCAGGACAGUCAUAGAACUGGCCUUGGGUGCUUGGGGAGAGUGGAGAGGUCUGGGGGGCAUCCACUGGCCUCAGCCUCAGAGCUUCUCAUCAGUAACCCAGGAGGCAAAGGCCCAGCUCAAGAUUAGCCCAGGCCACUGUAUCUGUGCCAAGACCUACAGCUGUCCCUGCAGGGCGUGCAUCUCUGCAGCCCAGGCUAUCACAAUGGUGUCCCUUUUGGUGGGGAUGUGAGGCCUGCUGCUGCCUGGGAAGAAGCUGACAGGAUUGUUGGUGCUGUGGGGAGAAGCUGGUGUAACUGAGACCCAUGAGGGAGGCCCUUUGUGGGUCUGUGGCUGGGAGGAGCUCUGGGGAAGAUGGGCCUUGAGAAAUCCCAGCUUAGCACCUUUGACAGUUGCUCCACUGAGUCACCCUAGACUGCAAUCUCACAGAUGUUCUAACCACCCUCUCCCUGGGGAGCCCUUGGGGGUGCUGCAAGCCCAGUCCUCACUCACUGGCUUUGUGCUUCUCUUCCCGACUUCCUUUUUUUGCUCCUGUUGAGAAAUGUGGGUCCAGGGCUGCGUGCUCCAGUGUGCGGAAGGAAGGGCAGCGUGCUCUUUGGACUGAGCUGGCUCAAGGGAAGCUGGGUCUGAGGGGAGACUGACCUCGACCCUUCUUAAAUGAAACACCUUUUCCCUGCGUCUCAGUCACCGUUACCUGGCCUGAUCACUGUGUGCCACACCCCAUCACAUCCAUCCCCACAAGAAUGCCAGGAGGAGGGGUCAUUGGCCUUUUUGUCAGCACAAACCUCUGGAGGCCCAGCUCCCAAGACCCGCCAGGCACACCUGCCAGAGUGCCUUAACUUGGGAUGUCUGCAAACCUCUGUCCAUGGCCGAACCCACCCCACUGCCUGUUACUGUAAAUAAAGGUCUAUUAGCAUGCCACCAUGCCCCUCCUCCGAUGCAUACAGUGCCCAGCUCAGCACCUGGUGCAAGUAAGCACAAUCUGGCUUCCAGCCAUCACUGCUGUUGCUACUAACACAAAUAUUAGGCCCCUUCUAGAAUGCAAAGAUAACCCAGGGCUGCUCGUUCUGUGUCCAGAUCACAGAGUUUUUCUUUUUAUCCUUAUCAACUUUAUUGAGGGAUAAUUUACAGGCAAUAAAUCAUAUCCAUUUAAAAAAAAAAAAAAAAAA

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Publications