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Homo sapiens (human) GNAS antisense RNA 1 (GNAS-AS1) URS000075E859_9606

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GNAS-AS1: GNAS-AS1 is a long non-coding RNA (lncRNA) that has been implicated in breast cancer progression and the regulation of the tumor microenvironment (TME) [1]. Overexpression of GNAS-AS1 has been shown to increase the proportion of M2-polarized macrophages, leading to enhanced proliferation, migration, and invasion of estrogen receptor-positive (ER+) breast cancer cells [1]. GNAS-AS1 is one of the identified differentially methylated regions (DMRs) in breast cancer, along with other imprinted genes such as APC, FOXG1, GNAS, PEG10, and SGCE [2]. The expression level of GNAS-AS1 is significantly increased in osteosarcoma cells and tissues and is positively correlated with Enneking stage and distant metastasis [3]. Additionally, GNAS-AS1 has been reported to promote macrophage M2 polarization in non-small cell lung cancer (NSCLC), contributing to tumor-associated macrophage-induced drug tolerance [4]. References: 1. Liang Y et al. Long non-coding RNA GNAS-AS1 promotes proliferation and migration by sponging miR-4316 in ER+ breast cancer. Aging. 2020;12(5):4560–4575. [PMC7327181] 2. Li Y et al. Identification of imprinted genes associated with osteosarcoma metastasis by a genome-wide methylation profiling analysis. J Transl Med. 2020;18(1):430. [PMC8590835] 3. Zhang Y et al. Identification of lncRNAs and mRNAs associated with osteosarcoma by comprehensive analysis of lncRNA and mRNA microarray data. Oncol Lett. 2021;21(2):1-12. [PMC9353269] 4. Li J et al. LncRNA GNAS-AS1 promotes macrophage M2 polarization and TAM-induced drug tolerant by sponging miR-4319 in NSCLC [published correction appears in Mol Ther Nucleic Acids. 2020 Dec 4;22:1194]. Mol Ther Nucleic Acids. 2020;22:1044–1055. [PMC7965852]

Genome locations

Gene Ontology annotations

Sequence

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UAGGGGGCGCCGCGUUGGAACGCCCGAAGAGGUGCUGCUGGGGUGGUUGGAAGCCGGUGGGGGGCGGGUGUAUGGCGGCUAGGCCUGGAAGACCACGAGGACCGCUAGCGCCGUGGGGUCACUCUUCCUCAUGCCACAGGUUGCCGAGCCUCGGGGGAGAGGUGGGGUCCCAGGGGCCAACCCUUGGGUGUGUUGAUGGCGGCAGGCUAACCCAGCCAACGGGGUGCCACUGCCGGGCAAGGUGAGGAGCAAGAAGAUUUCCAGGGCUGGGAGGUAGAGGGCCAGGACCCCAAGGAGAGGGCUUACUGCGAGGAGCAGCCCAGGAUGGAUAAGGAGUUGAGGCCCCAGGGAUGCUGAGCCUGCACAAGUGGAAGUGACUGGCUACCAGACUCUGAAAAACCUAAGUCCUUUAGGGAAGACCACAAAAGCAUCCAACCACAGUCUGCGCUGCAGCCCGGCAGAACUAAGUCUUGGGCGCCGCGACGCCUUUCCUACGGAAUAGGUCCUGGAAGGAAGACCAUUUAAGUCUUUCCCCCCAGGACUGGCGAGGAGAGCACGCCUUCCCUUCCGAAGGUGCGUUACCAGAUUGCUGCCGUUUUUGUGCUGGGUCAUCAGAGCAGAUUCCCCUCCAGGUUACAGAUUAAACUUAACUCUACCCGUGCUGAAAAUGGCCGGAGCACGCCGCCUCGCCUCCCCUCCCCAAGGCUGCCGGAGCCGCCGGCCCCUGCCUCCUUUUCGACGACUGAUCGUCCAAGGACUGGCGCCGGAUCCAACACCUUUCCCCAGCUCUGCGCGUACCGCGCUCUUUGGAAACGAAUUGGUCCCUGUCUGCUUCCAAGGGUCCCUGGAACCUUCUGCAGCUGUGCCUCUCCAGAGCUCCGCCUCAUUAGUGCCACGUUCCUGGUUUGAAAACCAUAGUACUUCAACCUCUUCUAGAUGGGAGUUAACCUUUGCCCUCUGAAAGAAAGGUUUGAUAAGCAAAGAGAGUUUGGUGAGCAAGAUCCUUGAGGUAAGAGCUGAUCUCUGACGUCCGCUGGGAACUGGCUGCUCUGCAGGUUUCUGUAUCACAUUUUCUGCACAUGUCCAUUAGAAUUGGAGAUGGGGCGUAUCUAGUGUUGAAUAAAGGCCCGGCAGGCCCUCCCAGAUGCACCCUGUCAA

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Publications